Search for dissertations about: "bioanalysis"

Showing result 6 - 10 of 29 swedish dissertations containing the word bioanalysis.

  2. 6. Analysis of drugs and proteins in biological matrices, using different types of sample preparations and mass spectrometry

    Author : Aljona Saleh; Ingrid Granelli; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioanalysis; drugs; proteins; liquid chromatography; two-dimensional liquid chromatography; mass spectrometry; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes bioanalysis of small and large molecules in biological matrices and includes screening of illegal drugs in urine with high resolution mass spectrometer, bioanalysis of MTH1 inhibitors in mice plasma and quantification of proteins in plasma and cell lysates.Screening of illegal drugs was based on high resolving power mass spectrometer (QTOF) and the results were compared to immunoassays. READ MORE

  4. 7. Mass spectrometry based analysis of endogenous sterols and hormones

    Author : Neil de Kock; Jonas Bergquist; Kumari Ubhayasekera; William J. Griffiths; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry; supercritical fluid chromatography; UPSFC–MS MS; bioanalysis; steroids; oxysterols; thyroid hormones; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Bioanalytical applications using supercritical fluid chromatography (SFC) as analytical technique are of increasing interest. In essence, bioanalysis involves measurement of bioactive or endogenous compounds in biological matrices. READ MORE

  5. 8. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    Author : Joel Tärning; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Abstract : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. READ MORE

  6. 9. MEMS Interfaces for Bioanalysis Systems

    Author : Thomas Frisk; Göran Stemme; Andreas Hierlemann; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; microfluidic interfacing; microfluidics; µTAS; sample transfer; biosensor; electronic nose; surface tension; quartz crystal microbalance; QCM; narcotics detection; Electronic measurement and instrumentation; Elektronisk mät- och apparatteknik;

    Abstract : This thesis deals with various aspects of using open microfluidic interfaces. Three specific areas of application are studied. The first is air-to-liquid interfacing in biosensors with possibilities for component inte­gration. A micromachined interface for airborne sample-to-liquid and droplet-to-liquid adsorption is discussed. READ MORE

  7. 10. A Novel Miniaturised Dynamic Hollow-Fibre Liquid-Phase Micro-Extraction Method for Xenobiotics in Human Plasma Samples

    Author : Helena Hansson; Ulrika Nilsson; Bo Karlberg; Peter Haglund; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sample clean-up; human blood plasma; hollow-fibre liquid phase microextraction; supported liquid membrane extraction; SLM; HF-LPME; sample preparation; bioanalysis; liquid-liquid extraction; Chemistry; Kemi; Analytical Chemistry; analytisk kemi;

    Abstract : Bioanalytical chemistry is a challenging field, often involving complex samples, such as blood, plasma, serum or urine. In many applications, sample cleanup is the most demanding and time-consuming step. READ MORE