Search for dissertations about: "biobanking"

Showing result 1 - 5 of 11 swedish dissertations containing the word biobanking.

  2. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Author : Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Keywords : breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Abstract : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). READ MORE

  4. 2. Morphological, immunohistochemical and genetic aspects of acinar and ductal adenocarcinoma of the prostate

    Author : Claes Lindh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostate cancer is one of the most common causes of cancer-related death in developed countries. Acinar adenocarcinoma is by far the most common subtype of prostate cancer, with ductal adenocarcinoma being the second most common subtype. READ MORE

  5. 3. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution

    Author : Mengqi Wang; Ulf Landegren; Anders Ståhlberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homogenous serological assay; PCR-based antibody detection; Proximity extension assay; SARS-CoV-2 antibody; Extracellular vesicles; Proximity barcoding assay; in situ superRCA; mutant transcript;

    Abstract : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. READ MORE

  6. 4. Trust in Biobank Research : Meaning and Moral Significance

    Author : Linus Johnsson; Mats G. Hansson; Gert Helgesson; Stefan Eriksson; Berge Solberg; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biobank; biobank research; bioethics; biobank ethics; research ethics; trust; trustworthiness; moral responsibility; informed consent; ethics review; ethics guidelines; Bioetik; Bioethics;

    Abstract : What role should trust have in biobank research? Is it a scarce resource to be cultivated, or does its moral significance lie elsewhere? How does it relate to the researcher’s individual responsibility?In this thesis I draw four general conclusions. First, trust is still very much present in at least some biobanking settings, notably in Sweden, but possibly also internationally. READ MORE

  7. 5. Bioinformatic methods for metagenomics and comparative genetics in veterinary medicine

    Author : Martin Norling; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Good science includes innovation, investigation, and rigor. This thesis’ first study is related to rigor. This study was performed at the International Livestock Research Institute (ILRI) in Nairobi, as part of the Arbovirus Incidence and Diversity (AVID) project. READ MORE