Search for dissertations about: "bioinformatics method"

Showing result 1 - 5 of 205 swedish dissertations containing the words bioinformatics method.

  2. 1. A Bioinformatics Study of Human Transcriptional Regulation

    Author : Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

    Abstract : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. READ MORE

  4. 2. Formalizing life : Towards an improved understanding of the sequence-structure relationship in alpha-helical transmembrane proteins

    Author : Håkan Viklund; Arne Elofsson; Kimmen Sjölander; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; protein; topology; hidden Markov model; prediction; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

    Abstract : Genes coding for alpha-helical transmembrane proteins constitute roughly 25% of the total number of genes in a typical organism. As these proteins are vital parts of many biological processes, an improved understanding of them is important for achieving a better understanding of the mechanisms that constitute life. READ MORE

  5. 3. A multivariate approach to computational molecular biology

    Author : Fredrik Pettersson; Michael Sjöström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; biomarker; Drosophila; SNP; linkage; disequilibrium; bioinformatics; computational; molecular; biology; genomics; microarray; SELDI; proteomics; Bioinformatics; Bioinformatik;

    Abstract : This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. READ MORE

  6. 4. Computational methods for analysis of fragmented sequence data

    Author : Fredrik Boulund; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; metagenomics; proteomics; sequencing; distributed computing; bioinformatics;

    Abstract : Recent developments in genomic and proteomic sequencing technologies have revolutionized research in life sciences, providing new opportunities for the study of biological systems. However, modern sequence data sets are large, diverse, and heavily fragmented, which presents new challenges for their analysis and interpretation. READ MORE

  7. 5. Bioinformatic Methods in Metagenomics

    Author : Johannes Alneberg; Anders F. Andersson; Lars Arvestad; Nicola Segata; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Metagenomics; Microbiome; Binning; Baltic Sea; Bioinformatik; Metagenomik; Mikrobiom; Binning; Östersjön;

    Abstract : Microbial organisms are a vital part of our global ecosystem. Yet, our knowledge of them is still lacking. Direct sequencing of microbial communities, i.e. READ MORE