Search for dissertations about: "bioinformatics tools"

Showing result 1 - 5 of 148 swedish dissertations containing the words bioinformatics tools.

2. 1. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

   Author : Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

   Abstract : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. READ MORE

4. 2. A Bioinformatics Study of Human Transcriptional Regulation

   Author : Adam Ameur; Jan Komorowski; Claes Wadelius; Philipp Bucher; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; microarray; ChIP-chip; ChIP-seq; transcription factor; histone modification; motif search; Bioinformatics; Bioinformatik;

   Abstract : Regulation of transcription is a central mechanism in all living cells that now can be investigated with high-throughput technologies. Data produced from such experiments give new insights to how transcription factors (TFs) coordinate the gene transcription and thereby regulate the amounts of proteins produced. READ MORE

5. 3. Tools and pipelines for interpreting the impacts of genetic variants

   Author : Abhishek Niroula; Proteinbioinformatik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Genetic variants; Machine Learning; cancer genomics; Variation interpretation;

   Abstract : Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. READ MORE

6. 4. eScience Approaches to Model Selection and Assessment : Applications in Bioinformatics

   Author : Martin Eklund; Jarl Wikberg; Ron Wehrens; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; high-throughout biology; eScience; model selection; model assessment; Bioinformatics; Bioinformatik;

   Abstract : High-throughput experimental methods, such as DNA and protein microarrays, have become ubiquitous and indispensable tools in biology and biomedicine, and the number of high-throughput technologies is constantly increasing. They provide the power to measure thousands of properties of a biological system in a single experiment and have the potential to revolutionize our understanding of biology and medicine. READ MORE

7. 5. Approaches for Distributing Large Scale Bioinformatic Analyses

   Author : Martin Dahlö; Ola Spjuth; Hedi Peterson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; cloud computing; HPC; high-performance computing; big data; kubernetes; spark; Bioinformatics; Bioinformatik;

   Abstract : Ever since high-throughput DNA sequencing became economically feasible, the amount of biological data has grown exponentially. This has been one of the biggest drivers in introducing high-performance computing (HPC) to the field of biology. READ MORE