Search for dissertations about: "biokemi med inriktning mot bioinformatik"

Showing result 1 - 5 of 39 swedish dissertations containing the words biokemi med inriktning mot bioinformatik.

  2. 1. Evolution of Interactions Involving Intrinsically Disordered Proteins

    Author : Emma Åberg; Per Jemth; Madan Babu; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; protein evolution; phylogenetics; ancestral sequence reconstruction; biophysical characterization; NCBD; CID; p53; MDM2; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biokemi; Biochemistry;

    Abstract : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. READ MORE

  4. 2. Development and Application of Molecular Modeling Methods for Structure-Based Drug Discovery

    Author : Axel Rudling; Jens Carlsson; Phillip Biggin; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Molecular modeling is increasingly being integrated into the drug discovery process. Although computational methods are already an essential part of the process today, these techniques have vast potential to evolve and refine drug design in the future. READ MORE

  5. 3. Decipher protein complex structures from sequence

    Author : Wensi Zhu; Arne Elofsson; Nathalie Reuter; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein complex structure prediction; protein interaction; AI; AlphaFold; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Proteins are essential constituents of biological systems. A profound understanding of protein structure is significant for unraveling the intricate mechanisms of biological processes. The recent development of computational methods using AI technology is revolutionizing the structural biology field. READ MORE

  6. 4. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

    Author : Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. READ MORE

  7. 5. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches

    Author : Christoffer Lind; Johan Åqvist; Alexander MacKerell Jr; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Binding free energy; Ribosome; Codon reading; Translation initiation; Translation termination; Mitochondrial translation; Release factor; Purine riboswitch; Molecular Dynamics; Free Energy Perturbation; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in turn, control the biochemical processes within the cell. It is thus of extreme importance that the machine that makes the proteins works with high precision. READ MORE