Search for dissertations about: "biokemi med inriktning mot bioinformatik"

Showing result 1 - 5 of 29 swedish dissertations containing the words biokemi med inriktning mot bioinformatik.

  1. 1. Evolution of Interactions Involving Intrinsically Disordered Proteins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emma Åberg; Uppsala universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; protein evolution; phylogenetics; ancestral sequence reconstruction; biophysical characterization; NCBD; CID; p53; MDM2; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biokemi; Biochemistry;

    Abstract : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. READ MORE

  2. 2. Development and Application of Molecular Modeling Methods for Structure-Based Drug Discovery

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Axel Rudling; Stockholms universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Molecular modeling is increasingly being integrated into the drug discovery process. Although computational methods are already an essential part of the process today, these techniques have vast potential to evolve and refine drug design in the future. READ MORE

  3. 3. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Masoud Kazemi; Uppsala universitet.; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE

  4. 4. Copy Number Analysis of Cancer

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Mayrhofer; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chromosomes; oncology; bioinformatics; Bioinformatik; Bioinformatics; Oncology; Onkologi; Clinical Genetics; Klinisk genetik;

    Abstract : By accurately describing cancer genomes, we may link genomic mutations to phenotypic effects and eventually treat cancer patients based on the molecular cause of their disease, rather than generalizing treatment based on cell morphology or tissue of origin.Alteration of DNA copy number is a driving mutational process in the formation and progression of cancer. READ MORE

  5. 5. Unveiling Mechanistic Details of Macromolecular Interactions: Structural Design and Molecular Modelling of DNA-Protein Systems in Their Active State

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Reymer; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular modelling; intercalation; homologous recombination; DNA; ruthenium II polypyridyl compounds; human Rad51;

    Abstract : Molecular structure is fundamental for understanding mechanisms of molecular interactions. This applies not least to understanding biological function: every biological cell, whether bacterial or human, is an immensely complex system of thousands of molecules that exist in constant motion and interaction with each other. READ MORE