Search for dissertations about: "biological networks"

Showing result 1 - 5 of 237 swedish dissertations containing the words biological networks.

  1. 1. Functional association networks for disease gene prediction

    Author : Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE

  2. 2. Dynamics in Random Boolean Networks

    Author : Björn Samuelsson; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gravitation; relativity; quantum mechanics; biomathematics biometrics; Bioinformatik; medicinsk informatik; biomatematik; Mathematical logic; set theory; combinatories; Matematisk logik; Mathematical and general theoretical physics; kombinatorik; mängdlära; classical mechanics; Bioinformatics; tissue simulations; transcription networks; random graphs; random maps; nested canalyzing; canalyzing; genetic regulation; Kauffman networks; random Boolean networks; statistical physics; thermodynamics; medical informatics; Matematisk och allmän teoretisk fysik; klassisk mekanik; kvantmekanik; relativitet; termodynamik; statistisk fysik;

    Abstract : There are many examples of complex networks in science. It can be genetic regulation in living cells, computers on the Internet, or social and economic networks. In this context, Boolean networks provide simplistic models that are relatively easy to handle using computer simulations and mathematical methods. READ MORE

  3. 3. Global functional association network inference and crosstalk analysis for pathway annotation

    Author : Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; biokemi med inriktning mot bioinformatik; Biochemistry towards Bioinformatics;

    Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE

  4. 4. Reconstruction of Biological Networks for Integrative Analysis

    Author : Tobias Österlund; Chalmers University of Technology; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcriptional regulation; : Biological networks; integrative analysis; protein secretion; genome-scale metabolic model;

    Abstract : Biological systems can be very complex and consist of several thousand components that interact with each other in the cell. One of the goals of systems biology is to study biological systems from a systemic viewpoint in order to get an increased understanding of the behavior of the cell. READ MORE

  5. 5. Robust inference of gene regulatory networks : System properties, variable selection, subnetworks, and design of experiments

    Author : Torbjörn E. M. Nordling; Elling W Jacobsen; Rolf Findeisen; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURAL SCIENCES; NATURAL SCIENCES; ENGINEERING AND TECHNOLOGY; network inference; reverse engineering; variable selection; model selection; feature selection; subset selection; system identification; system theory; network theory; subnetworks; design of experiments; perturbation experiments; gene regulatory networks; biological networks;

    Abstract : In this thesis, inference of biological networks from in vivo data generated by perturbation experiments is considered, i.e. deduction of causal interactions that exist among the observed variables. Knowledge of such regulatory influences is essential in biology. READ MORE