Search for dissertations about: "biologisk kemi"

Showing result 1 - 5 of 44 swedish dissertations containing the words biologisk kemi.

  1. 1. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation

    Author : Sandra Behren; Ulrika Westerlind; Mikael Elofsson; Carmen Galan; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Glycopeptides; mucins; mucin type-O-glycosylation; microarrays; tyrosine-O-HexNAcylation; lectins; MUC1 cancer vaccines; TcdA; LecB; galectins; LacdiNAc; antibodies; biologisk kemi; biological chemistry; Biorganic Chemistry; bioorganisk kemi; organisk kemi; Organic Chemistry;

    Abstract : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. READ MORE

  2. 2. Aspects of Porous Graphitic Carbon as Packing Material in Capillary Liquid Chromatography

    Author : Anna Törnkvist; Wolfgang Lindner; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; PGC; porous graphitic carbon; stationary phase; packing material; LC; liquid chromatography; miniaturized; chiral; enantiomer; ESI; electrospray ionization; mass spectrometry; polar compounds; L-DOPA; dopamine; biological samples; biological matrix; Analytisk kemi; PGC; poröst grafitiserat kol; stationärfas; packningsmaterial; LC; vätskekromatografi; miniatyriserade system; kiral; enantiomer; ESI; electrospray jonisation; mass spektrometri; polära föreningar; L-DOPA; dopmamine; biologiska prover; biologisk matris; Analytical chemistry; Analytisk kemi; Analytical Chemistry; Analytisk kemi;

    Abstract : In this thesis, porous graphitic carbon (PGC) has been used as packing material in packed capillary liquid chromatography. The unique chromatographic properties of PGC has been studied in some detail and applied to different analytical challenges using both electrospray ionization-mass spectrometry (ESI-MS) and ultra violet (UV) absorbance detection. READ MORE

  3. 3. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

    Author : Viveca Thornqvist; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Kemi; Organic chemistry; Organisk kemi; Chemistry; Natural science; paclitaxel; spiro; indium; Naturvetenskap; bicyclo[2.2.2]octane; allylation; paclitaxel mimetic;

    Abstract : Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). READ MORE

  4. 4. An insight into the metabolism of New Psychoactive Substances : Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues using synthesized reference standards

    Author : Jakob Wallgren; Johan Dahlén; Peter Konradsson; Xiongyu Wu; Mogens Johannsen; Linköpings universitet; []

    Abstract : New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. READ MORE

  5. 5. Biolubricants and Biolubrication

    Author : Min Wang; Andra Dėdinaitė; Per Claesson; Esben Thormann; Holmberg Krister; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Hyaluronan; Phospholipid; Lubricin; Cartilage Oligomeric Matrix Protein; COMP; Adsorption; Surface Force; Friction; Biolubrication; Boundary Lubrication; Load Bearing Capacity; Synergistic Effects; DLS; QCM-D; AFM.; Hyaluronan; Fosfolipid; Lubricin; Cartilage Oligomeric Matrix Protein; COMP; Adsorption; Ytkraft; Friktion; Biologisk smörjning; Gränsskiktssmörjning; Lastbärande förmåga; Synergieffekter; DLS; QCM-D; AFM.; Kemi; Chemistry;

    Abstract : The main objective of this thesis work was to gain understanding of the principles of biolubrication, focusing on synergistic effects between biolubricants. To this end surface force and friction measurements were carried out by means of Atomic Force Microscopy, using hydrophilic and hydrophobic model surfaces in salt solutions of high ionic strength (≈ 150 mM) in presence of different biolubricants. READ MORE