Search for dissertations about: "biomarker conversion"

Showing result 1 - 5 of 12 swedish dissertations containing the words biomarker conversion.

  2. 1. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

    Author : Siker Kimbung; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

    Abstract : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. READ MORE

  4. 2. Volumetric assessment of hippocampus and cerebral white matter lesions in structural MRI

    Author : Erik Olsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; structural MRI; white matter lesions; hippocampal volumetry; reliability; mild cognitive impairment; dementia; low dose radiation;

    Abstract : Assessment in structural MRI like hippocampal volumetry and white matter lesion (WML) assessment is receiving widespread attention and recommen-dation as important research and diagnostic tools. The aim in this thesis is to contribute to enhanced reliability and validity in structural MRI assessment. READ MORE

  5. 3. Neuroimaging biomarkers in Alzheimer’s disease

    Author : Farshad Falahati Asrami; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is characterized by an accumulation of abnormal plaques and tangles in the brain, a process that is estimated to begin years before the appearance of clinical symptoms. Individuals with subjective memory decline (SMD) or mild cognitive impairment (MCI) run a higher risk of developing AD than cognitively normal (CN) people. READ MORE

  6. 4. Predictors of cognitive decline in memory clinic patients

    Author : Christin Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: The major challenge in memory clinics is to predict development as well as non-development of dementia among the heterogeneous group of patients with cognitive complaints. Since the advent of pharmacological treatment possibilities for patients with Alzheimer s disease (AD), much research has been focused on predictors for dementia since initiation of treatment in the preclinical phase may prevent development of dementia. READ MORE

  7. 5. Biomarkers as Monitors of Drug Effect, Diagnostic Tools and Predictors of Deterioration Rate in Alzheimer’s Disease

    Author : Malin Degerman Gunnarsson; Lena Kilander; Hans Basun; Jan Marcusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; biomarkers; CSF; PIB PET; amyloid-beta; tau; rapid cognitive decline; dying in severe dementia; mortality; neuropsychological tests; Medicinsk vetenskap; Medical Science;

    Abstract : Decreased amyloid-ß42 (Aß42), increased total tau (t-tau) and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) reflect histopathological core changes in the most common dementia disorder, Alzheimer’s disease (AD). They discriminate AD from healthy controls and predict conversion to AD with a relatively high accuracy. READ MORE