Search for dissertations about: "biomarker for Obesity"

Showing result 1 - 5 of 28 swedish dissertations containing the words biomarker for Obesity.

2. 1. Methods for Analyzing Genomes

   Author : Patrik L. Ståhl; Joakim Lundeberg; Ivo Gut; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; array; sequence capture; genotyping; trinucleotide threading; sequencing; massively parallel sequencing; single molecule sequencing; Visual DNA; p53; single nucleotide polymorphism; biomarker; Genetics; Genetik;

   Abstract : The human genome reference sequence has given us a two‐dimensional blueprint of our inherited code of life, but we need to employ modern‐day technology to expand our knowledge into a third dimension. Inter‐individual and intra‐individual variation has been shown to be larger than anticipated, and the mode of genetic regulation more complex. READ MORE

4. 2. Lifestyle and glycaemic control before and after the onset of type 2 diabetes

   Author : Robert Koivula; Genetisk och molekylär epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Prediabetes; Obesity; Beta-cell Function; Insulin Sensitivity; Physical Activity; Exercise; Diet; Lifestyle; Ectopic Fat; Genetic Epidemiology; Genetic Risk; Biomarker; Precision Medicine;

   Abstract : Type 2 diabetes (T2D) is a complex disease with widespread physiological insults to the regulation of metabolic homeostasis, above all glycaemic regulation. The pathogenesis of T2D and its progression is broadly understood to be through a gradual decrease in peripheral insulin sensitivity, a compensatory rise in insulin secretion, and a gradual decline in beta-cell function, resulting in glycaemic dysregulation and eventual T2D. READ MORE

5. 3. Dietary Intake, Fatty Acid Biomarkers, and Abdominal Obesity : Population-Based Observational Studies

   Author : Zayed Alsharari; Ulf Risérus; Matti Marklund; Per Sjögren; Tommy Cederholm; Emily Sonestedt; Uppsala universitet; []
   Keywords : abdominal obesity; fatty acid biomarker; dietary intake; Kostvetenskap; Food; Nutrition and Dietetics;

   Abstract : The aim of this thesis was to investigate the associations between fatty acid (FA) biomarkers, carbohydrate intake, and abdominal obesity (AO) and related anthropometric measures in a population-based cohort of men and women in Stockholm County. The overall hypothesis was that dietary fat quality assessed by serum and adipose tissue FA composition, and dietary intake of especially carbohydrates is associated with AO. READ MORE

6. 4. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

   Author : Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. READ MORE

7. 5. Genetic and phenotypic discordance in cardiometabolic diseases

   Author : Daniel Coral; Genetisk och molekylär epidemiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; Diabetes; Cardiovascular disease; Genome-wide association studies; Heterogeneity;

   Abstract : Cardiometabolic conditions such as obesity and type 2 diabetes (T2D) are among the first causes of death globally, and the number of people affected is rapidly increasing. Both conditions are intricately connected and are associated with many life-threatening cardiovascular disease (CVD). READ MORE