Search for dissertations about: "biomarker"

Showing result 1 - 5 of 571 swedish dissertations containing the word biomarker.

  2. 1. Proteomic Analysis of Urinary Bladder Cancer Aiming for Novel Biomarkers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mårten Lindén; Per-Uno Malmström; Ulrika Segersten; Sara Bergström Lind; Lars Egevad; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urine; APOE; FGB; GAL1; LRG1; POLR1E; SERPINA1; STMN1; TOP2A; biomarker; diagnostic biomarker; prognostic biomarker; predictive biomarker; mass spectrometry; western blot; dot blot; immunohistochemistry; IHC; tissue microarray; TMA; urothelium; antibody; antibody-based; urinblåsecancer; biomarkör; diagnos; prognos; urin; proteomik; masspektrometri; immunohistokemi; antikroppar; Molecular Biology; Molekylärbiologi; Molekylär medicin; Molecular Medicine;

    Abstract : Urinary bladder cancer is a heterogeneous disease appearing in different forms, e.g. non-muscle invasive and muscle invasive. For all variants, the expression of proteins is interesting to analyze for diagnostic, predictive, prognostic and drug targeting purposes, since it reflects the altered gene expression causing the cancer. READ MORE

  4. 2. Proteomics in biomarker research Insights into the effects of aging and environment on biological systems

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Hanna Amelina; Susana Cristobal; Jean-Charles Sanchez; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; proteomics; biomarker; peroxisomes; 2-dimensional gel electrophoresis 2-DE ; mass spectrometry MS ; aging; marine pollution; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; NATURAL SCIENCES Chemistry Environmental chemistry Environmental toxicology; NATURVETENSKAP Kemi Miljökemi Miljötoxikologi; NATURAL SCIENCES Biology Cell and molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi; biokemi; Biochemistry;

    Abstract : Proteomics is the global analysis of proteins that covers a broad range of technologies aimed at determining the identity and quantity of proteins expressed in the cell, their three-dimensional structure and interaction partners. In contrast to genome, proteome reflects more accurately on the dynamic state of the cell, tissue, or an organism. READ MORE

  5. 3. Strategies for Miniaturized Biomarker Detection

    University dissertation from Department of Biomedical Engineering, Lund university

    Author : Belinda Adler; [2014]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biomarker; miniturization; lab-on-a-chip; proteomics; PSA; microarray; mass spectrometry; MALDI MS; SPE; sample preparation; immunoaffinity; antibody; aptamer; mass tag; ISET.;

    Abstract : The aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. READ MORE

  6. 4. Evaluation of Biomarker Responses in Fish with Special Emphasis on Gill EROD Activity

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Carin Andersson; Uppsala universitet.; [2007]
    Keywords : Biology; three-spined stickleback; biomarker; EROD; ethynylestradiol; gill; vitellogenin; spiggin; CYP1A inducers; humic substances; sperm quality; biomonitoring; Biologi;

    Abstract : Many chemicals present in the aquatic environment can interfere with physiological functions in fish. Exposure to chemicals can be revealed by the use of biomarkers. Induction of 7-ethoxyresorufin O-deethylase (EROD) activity is a commonly used biomarker for exposure to CYP1A inducers such as dioxins and polyaromatic hyrdrocarbons. READ MORE

  7. 5. Biomarker Discovery in Cutaneous Malignant Melanoma A Study Based on Tissue Microarrays and Immunohistochemistry

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; MEDICINE Morphology; cell biology; pathology Morphology Tumour biology; MEDICIN Morfologi; cellbiologi; patologi Morfologi Tumörbiologi; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; MEDICINE Morphology; cell biology; pathology Pathology Molecular medicine; MEDICIN Morfologi; cellbiologi; patologi Patologi Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

    Abstract : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. READ MORE