Search for dissertations about: "biomolecular detection"
Showing result 11 - 15 of 47 swedish dissertations containing the words biomolecular detection.
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11. Application of proximity Ligation for Detection of Proteins, Biomolecular Interactions, and Single Copies of Pathogens
Abstract : Proximity ligation is a recently established technique that can provide answers to questions about the concentration, localization, interactions, modifications and functions of proteins. The method enables sensitive protein measurements with a detection limit in the low femtomolar range in complex biological samples. READ MORE
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12. Probing Biomolecular Recognition at the Single Molecule Level
Abstract : Specific recognition between biomolecular partners contributes to a multitude of biochemical signaling within and between cells. The aim of this work has been to investigate the possibility to probe biomolecular recognition reactions at the smallest possible scale, the single molecule level. READ MORE
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13. Development of Electroacoustic Sensors for Biomolecular Interaction Analysis
Abstract : Biomolecular interaction analysis to determine the kinetics and affinity between interacting partners is important for the fundamental understanding of biology, as well as for the development of new pharmaceutical substances. A quartz crystal microbalance instrument suitable for kinetics and affinity analyses of interaction events was developed. READ MORE
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14. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy
Abstract : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. READ MORE
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15. Microfluidic analysis and parallel confocal detection of single molecules
Abstract : The detection of single molecules using confocal spectroscopy is of major interest and tremendous improvements have been made within the last decade. The underlying basics, however, a pinhole and a single excitation volume element have remained the same as well as the technical limitations. READ MORE