Search for dissertations about: "biopharmaceutical drugs"
Showing result 1 - 5 of 11 swedish dissertations containing the words biopharmaceutical drugs.
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1. China's Creation of Biopharmaceutical Drugs : Combining Political Steering, Military Research, and Transnational Networking
Abstract : Not only the Western world is focused on creating new innovations based on scientific discoveries; this is also the case in China where discoveries in biotechnology science are aimed at creating new biopharmaceutical drugs in order to create a future biotechnology industry and in the end generate economic growth. The focus to invest in high-tech industries such as biotechnology can be traced to the “open-door policy” issued in 1978 with the aim to modernize China and transform China into a “socialistic market economy. READ MORE
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2. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients
Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE
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3. Tailormade Surfaces for Extended CE Applications
Abstract : The combination of capillary electrophoresis (CE) and mass spectrometry (MS) constitutes a powerful microanalytical system in the fields of biology, medicine and chemistry. This thesis describes the development of three novel capillary coatings and demonstrates how these extend the utility of CE as a high-efficiency separation technique in protein analysis and biopharmaceutical drug screening. READ MORE
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4. Biopharmaceutical aspects of intestinal drug absorption : Regional permeability and absorption-modifying excipients
Abstract : Before an orally administered drug reaches the systemic circulation, it has to dissolve in the intestinal fluids, permeate across the intestinal epithelial cell barrier, and pass through the liver. The permeation rate of drug compounds can be low and show regional differences.The thesis had two general aims. READ MORE
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5. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach
Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE
