Search for dissertations about: "biopharmaceutical thesis"

Showing result 21 - 25 of 34 swedish dissertations containing the words biopharmaceutical thesis.

  2. 21. Computational models for the prediction of intestinal membrane permeability

    Author : Patric Stenberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : Lead compounds generated in high-throughput drug discovery programs often have unfavorable biopharmaceutical properties, resulting in a low success rate for such drug candidates in clinical development. Efficient and reliable methods that predict biopharmaceutical properties, such as intestinal permeability and solubility are therefore required in order to reduce the attrition rate during development of these compounds. READ MORE

  4. 22. Development of Nanocellulose Materials for Nano-filtration and Microfluidic Cell Culture

    Author : Lulu Wu; Maria Tenje; Natalia Ferraz; Pasi Kallio; Margareta Krabbe; Lars Evenäs; Caroline Adiels; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cellulose nanofibrils; plasma-derived biologics; virus removal filtration; microfluidics; cell alignment; topography; shear stress.;

    Abstract : Nanocellulose, cellulose nanofibrils or nanocrystals, is an interesting material for a wide range of applications. It can be obtained from abundant sources (higher plants, bacteria and algae), and presents many advantages to be used in the biomedical field such as biological safety, high surface area, porosity, and tailorable rheological properties. READ MORE

  5. 23. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    Author : Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE

  6. 24. Cryogels as Solid Supports in Bioprocessing

    Author : Gry Jespersen; Bioteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Downstream processing; cryogel; solid support; biomacromolecules; chromatography;

    Abstract : In recent years the market for biopharmaceutical products has been increasing rapidly as a result of an increased demand for new and efficient treatments of various indications. Biopharmaceuticals are distinguished from chemical drugs by being derived from a biological origin and are hence, frequently constituting biological macromolecules. READ MORE

  7. 25. Engineering the Secretory Pathway for Recombinant Protein Secretion in Saccharomyces cerevisiae

    Author : Jichen Bao; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; endoplasmic reticulum; oxidative stress; GLO3; protein secretion; transcriptomics; drug screening; Saccharomyces cerevisiae; SEC16;

    Abstract : In the past few decades there has been an increasing demand of biopharmaceutical proteins in the market. Several types of cell factories are applied to produce different pharmaceutical proteins. READ MORE