Search for dissertations about: "biopharmaceutical thesis"

Showing result 6 - 10 of 34 swedish dissertations containing the words biopharmaceutical thesis.

  2. 6. Modeling for Quality and Safety in Biopharmaceutical Production Processes

    Author : Karin Westerberg; Avdelningen för kemiteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Process modeling; chromatography; quality by design; robustness; process control;

    Abstract : To design efficient and safe biopharmaceutical production processes, understanding the process and how it is affected by changes in the process conditions is essential. Experimental data form the basis of this understanding which can be enhanced by modeling and simulations of the physical and chemical processes known to control the process. READ MORE

  4. 7. Analytical Quality by Design Method Development for Vaccine Characterization

    Author : Lars Geurink; Catharina Sänger van de Griend; Mikael Hedeland; Martijn Schenning; Iulia Oita; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; viral vaccines; adenovirus; influenza; polio; COVID; corona; capillary electrophoresis; analytical quality by design; analytical method development; CGE; icIEF; CZE; crude cell suspension analysis; in-process sample analysis; quality control testing; biopharmaceutical characterization; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Vaccines that are safe, efficacious, and can be rapidly developed are needed to prevent and to react to emerging global infectious disease threats such as influenza, Polio, and Coronavirus diseases. Fast and reliable analytical methods are required without delay to support vaccine process and product development, characterization, and quality control testing. READ MORE

  5. 8. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis

    Author : Eivor Örnskov; Staffan Folestad; Karin E. Markides; Morteza Khaledi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis CE ; micellar electrokinetic chromatography MEKC ; drug; liposome; microemulsion; coating; pKa; lipophilicity; multivariate analysis; molecular descriptor; hierarchical analysis; passiv absorption; Analytisk kemi; Analytical chemistry; Analytisk kemi;

    Abstract : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. READ MORE

  6. 9. Biopharmaceutical Evaluation of Intra-arterial Drug-Delivery Systems for Liver Cancer : Investigations in healthy pigs and liver cancer patients

    Author : Elsa Lilienberg; Hans Lennernäs; Erik Sjögren; Niklas Axén; Helen M. Burt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in vivo release; drug delivery systems; local delivery; drug disposition; doxorubicin; hepatocellular carcinoma; transarterial chemoembolization; transarterial chemotherapy infusion; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : There are currently two types of intra-arterial drug-delivery system (DDS) in clinical use in the palliative treatment of primary liver cancer. The chemotherapeutic drug doxorubicin (DOX) can be formulated into a drug-in-lipiodol emulsion (LIPDOX) or a microparticulate drug-eluting bead system (DEBDOX). READ MORE

  7. 10. Biopharmaceutical aspects of extended release tablets based on the hydrophilic matrix principle

    Author : Bertil Abrahamsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE