Search for dissertations about: "biophysical characterization"

Showing result 1 - 5 of 37 swedish dissertations containing the words biophysical characterization.

  2. 1. On diverse biophysical aspects of genetics : from the action of regulators to the characterization of transcripts

    Author : Aymeric Fouquier D´Hérouel; Erik Aurell; Felix Ritort; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; transcription regulation; regulatory motifs; binding affinity; genetic interactions; secondary structure; sequence repeats; transcript characterization; Biological physics; Biologisk fysik;

    Abstract : Genetics is among the most rewarding fields of biology for the theoretically inclined, offering both room and need for modeling approaches in the light of an abundance of experimental data of different kinds. Many aspects of the field are today understood in terms of physical and chemical models, joined by information theoretical descriptions. READ MORE

  4. 2. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs

    Author : Patricia Wennerstrand; Lars-Göran Mårtensson; Curt Peterson; Malin Lindqvist Appell; Mikael Widersten; Linköpings universitet; []
    Keywords : ;

    Abstract : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. READ MORE

  5. 3. Optical characterization of potential drugs and drug delivery systems

    Author : Erik Rosenbaum; Lennart B-Å Johansson; Sven Engström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pilicide; Ganglioside GM1 micelles; Drug Delivery; Elecronic Energy Transfer; UV-Vis Absorption; Fluorescence Spectroscopy; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

    Abstract : This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. READ MORE

  6. 4. Evolution of Interactions Involving Intrinsically Disordered Proteins

    Author : Emma Åberg; Per Jemth; Madan Babu; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; protein evolution; phylogenetics; ancestral sequence reconstruction; biophysical characterization; NCBD; CID; p53; MDM2; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Biokemi; Biochemistry;

    Abstract : This thesis describes the evolution of intrinsically disordered proteins and their interaction partners. The work presented is a combination of phylogenetic analysis, ancestral reconstruction and biophysical characterization in order to examine the evolutionary trajectory of protein-protein interactions involving disorder. READ MORE

  7. 5. Characterization of α-synuclein oligomers : Implications for Lewy Body Disorders

    Author : Thomas Näsström; Martin Ingelsson; Joakim Bergström; Lars Lannfelt; Poul Henning Jensen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Alpha-synuclein; Lewy bodies; Oligomers; Reactive aldehydes; monoclonal antibody; Medical Science; Medicinsk vetenskap;

    Abstract : Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy are disorders featuring accumulation of Lewy bodies in brain. The main component of these large insoluble intracellular inclusions is the presynaptic protein alpha-synuclein (α-synuclein). READ MORE