Search for dissertations about: "biotin"

Showing result 6 - 10 of 59 swedish dissertations containing the word biotin.

  2. 6. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

    Author : Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

    Abstract : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. READ MORE

  4. 7. Pretargeting agents and At-211-labeled effector molecules: Synthesis and preclinical evaluation for pretargeted alpha-radioimmunotherapy

    Author : Sofia Frost; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha particles; astatine-211; avidin; biotin; ovarian cancer; polylysine; pretargeted radioimmunotherapy;

    Abstract : .... READ MORE

  5. 8. Affinity-, Partition- and Permeability Properties of the Human Red Blood Cell Membrane and Biomembrane Models, with Emphasis on the GLUT1 Glucose Transporter

    Author : Christine Lagerquist Hägglund; Per Lundahl; Jørgen Vinten; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Affinity; Aromatic amino acids; Binding; Biomembrane; Biotin; Chromatography; Cytochalasin B; Dihydrocytochalasin B; Dissociation constant; Drug absorption; Ethanol; Equilibrium; Glucose; GLUT1; Immobilization; Immobilized biomembrane affinity chromatography; Immobilized liposome chromatography; Interaction; Liposome; Membrane protein; Membrane vesicle; Partitioning; Phospholipid bilayer; Proteoliposome; Quantitative; Red blood cell; Specific; Streptavidin; Tyrosine; Tryptophan; Biokemi; Biochemistry; Biokemi;

    Abstract : The human glucose transporter GLUT1 is abundant in red blood cells, the blood-brain barrier and epithelial cells, where it mediates the transport of the energy metabolite, glucose. In the present work some properties of GLUT1, including affinity binding of both substrates and inhibitors, transport rates as well as permeabilities of aromatic amino acids and drug-membrane interactions were analyzed by chromatographic methods. READ MORE

  6. 9. Enzymatic mechanisms in biotin synthesis : vitamin B6 catalysis and phosphoryl transfer

    Author : Jenny Sandmark; Karolinska Institutet; Karolinska Institutet; []
    Keywords : X-ray crystallography; biotin biosynthesis; pyridoxal-5 -phosphate; aminotransferase; aluminium fluoride; S-adenosyl-L-methionine; 7; 8-diaminopelargonic acid synthase; dethiobiotin synthetase; biotin; phosphoryl transfer; amiclenomycin.;

    Abstract : With the large number of pathogenic bacteria that have developed antibiotic resistance it is increasingly important to find new targets for antibiotics. Our interest in the biotin biosynthesis pathway originates from this drug design perspective. All organisms require biotin, but it is only synthesised in bacteria, in plants and in some fungi. READ MORE

  7. 10. Synthetic Paper for Point-of-Care Diagnostics : Capillary control, surface modifications, and their applications

    Author : Weijin Guo; Wouter van der Wijngaart; Jonas Hansson; Govind V. Kaigala; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; capillary pump; lateral flow test; synthetic paper; OSTE; microarray; point-of-care; surface energy; viscosity; enrofloxacin; plasma separation; protein recovery rate; agglutination; antibody; glass; nitrocellulose; hydrophilic treatment; click chemistry; thiol-yne; thiol-maleimide; biotin-streptavidin; kapillärpump; lateral flödesprov; syntetiskt papper; OSTE; mikroarray; point-of-care; ytenergi; viskositet; enrofloxacin; plasmaseparation; proteinåtervinningshastighet; agglutination; antikropp; glas; nitrocellulosa; hydrofil behandling; klickkemi; tiol-yne; tiol-maleimid; biotin-streptavidin; Electrical Engineering; Elektro- och systemteknik;

    Abstract : Capillary-based platforms for diagnostics are popular for the point-of-care diagnostics market because of their low cost, easy fabrication, and easy operation. Lateral flow tests are an excellent example of capillary-based platforms for point-of-care diagnostics. READ MORE