Search for dissertations about: "blood-brain barrier"

Showing result 11 - 15 of 189 swedish dissertations containing the words blood-brain barrier.

  2. 11. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    Author : Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

  4. 12. Design, expression, and analysis of antibody-based blood-brain barrier shuttles

    Author : Andrés de la Rosa; Greta Hultqvist; Paul O'Callaghan; Nicole G. Metzendorf; Torben Moos; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody therapeutics; transient gene expression; protein production; blood-brain barri-er BBB ; BBB shuttle; brain delivery; Transferrin receptor TfR ; heparan sulfate; holo-transferrin; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : Antibody therapeutics, with their strong and highly selective target binding, are now used to treat various diseases. However, to enable their use to treat brain disorders, they must be delivered across the blood-brain barrier (BBB), as without active transport, only around 0.01% of intravenously injected doses reach the brain. READ MORE

  5. 13. Cell-penetrating peptides targeting glioblastomas for nucleic acid delivery in the blood-brain barrier model

    Author : Artita Srimanee; Ülo Langel; Ines Neundorf; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Blood-brain barrier model; nucleic acid delivery; glioblastomas; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Glioblastoma multiforme is the most aggressive form of malignant brain tumor with poor prognosis. The efficacy of brain cancer treatment by chemotherapeutics is limited by the blood-brain barrier (BBB) which allows less than 2% of the small molecules and blocks almost all the macromolecules to transport into the brain. READ MORE

  6. 14. Gut microbiota to counteract metabolic disorders and neuroinflammation : Impact of dietary factors and their potential to prevent Alzheimer’s disease

    Author : Nittaya Marungruang; Avdelningen för livsmedel och läkemedel; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; gut microbiota; metabolic disorders; inflammation; neuroinflammation; lingonberries; dietary fibre; gut barrier; blood-brain barrier;

    Abstract : Alzheimer’s disease (AD) is the most common form of dementia. Increased accumulations of senile plaques and tangles are the known neuropathological hallmarks of AD. However, the exact triggers for such protein accumulations, leading to cognitive impairment and important morphological alteration in AD, are still elusive. READ MORE

  7. 15. Inflammatory Signaling Across the Blood-Brain Barrier and the Generation of Fever

    Author : Anna Eskilsson; David Engblom; Annika Thorsell; Göran Engberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Fever is a cardinal sign of inflammation and is evolutionary conserved. Fever is known to be beneficial during acute inflammation, but over time and if very high it can be detrimental. READ MORE