Search for dissertations about: "bls"

Showing result 16 - 20 of 20 swedish dissertations containing the word bls.

  2. 16. Functional characterization of the alternative reading frame protein p14ARF

    Author : Mikael Lindström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : p14ARF; p19ARF; alternative reading frame; CDKN2A; p53; B23; nucleophosmin; Burkitt´s lymphoma; nucleolus; senescence; Myc; E2F; phosphorylation; RNA interference; ribosome biogenesis;

    Abstract : A deeper understanding of the molecular events underlying tumor development is a prerequisite for the design of novel and efficient therapies. Inactivation of the p53 and retinoblastoma (Rb) tumor suppressor pathways appears as a common theme in most malignant human tumors. READ MORE

  4. 17. Dual dispatch and the importance of bystander CPR in out-of-hospital cardiac arrest

    Author : Ingela Hasselqvist-Ax; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background and aim: Survival after out-of-hospital cardiac arrest (OHCA) remains low. In Sweden in 2016, of 5312 cases reported to the Swedish Register of Cardiopulmonary Resuscitation (SRCR), only 577 (11%) survived to 30-days. READ MORE

  5. 18. Expression and function of the small immune adaptor protein SAP

    Author : Noemi Nagy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : XLP; SAP; EBV; BL; lymphocytes; lymphoma; p53; apoptosis; AICD;

    Abstract : The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with a rare hereditary immunodeficiency, X-linked lymphoproliferative disease (XLP), primary infection with E13V has a fatal course. READ MORE

  6. 19. Modulation of cellular and viral functions in Epstein-Barr virus infected cells

    Author : Marta P Imreh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of the study was to investigate the interplay of cellular and viral genes in Epstein-Barr virus (EBV) infected cells. Two aspects of this interaction have been investigated. The first aspect is related to the expression of major histocompatibility complex (MHC) class I molecules in virus infected malignant cells. READ MORE

  7. 20. Role of Tripeptidyl peptidase II in cell cycle regulation and tumor progression

    Author : Vaia Stavropoulou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Apoptosis; Burkitt s lymphoma; cell cycle; centrosome; genetic instability; Golgi; mitosis; tripeptidyl-peptidase II;

    Abstract : Protein degradation is essential for many cellular functions and the ubiquitin-proteasome system controls the turnover of most cellular proteins and plays a pivotal role in the regulation of basic physiological processes and in the pathogenesis of many diseases. Alterations in the metabolism of proteins involved in the regulation of cell cycle and apoptosis may result in uncontrolled cell division, which em lead to malignant transformation and tumor development One melt example is the Burkitt's lymphoma (BL), a highly malignant B-cell tumor characterized by chromosomal translocations that constitutively activate the c-myc oncogene. READ MORE