Advanced search

Showing result 1 - 5 of 13 swedish dissertations matching the above criteria.

  2. 1. Heterocyclic peptide mimetics derived from boc-amino acids : design, synthesis and incorporation in substance P and dermorphin

    Author : Susanna Borg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 2. Development and characterisation of protecting groups that enhance the solubility of synthetic peptides : Methods to improve the aqueous solubility of hydrophobic peptides

    Author : Karolina Wahlström; Anders Undén; Fernando Albericio; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Solid phase peptide synthesis; Fmoc chemistry; solubility problems; tryptophan; tyrosine; Nmec; Nmbu; Bioorganic chemistry; Bioorganisk kemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Chemical synthesis of peptides is generally performed by solid phase peptide synthesis (SPPS). Although SPPS is a rapid and convenient method to prepare peptides, the major methodological problem in SPPS is related to solvation/solubility. READ MORE

  5. 3. Development of a new protective group for tryptophan

    Author : Marie Danielsson; Anders Undén; Amelie Karlström; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : A new protective group for the indole nitrogen of the amino acid tryptophan, the Boc-sarcosinoyl-sarcosinolyl (Boc-Sar-Sar) is described. This protective group shows good stability to the reaction conditions used in solid phase peptide synthesis and is incorporated into the peptide as FmocTrp(BocSarSar)OH. READ MORE

  6. 4. Granulocyte activation by danger signals and blocking of receptor responses

    Author : Anna-Lena Stenfeldt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; granulocytes; neutrophils; eosinophils; danger signals; danger theory; formyl peptide receptors; antagonists; inhibitors;

    Abstract : Granulocytes are the most abundant cells in the peripherial blood. They serve to eliminate invading microbes and parasites and release anti-microbial agents. In the event of injury, granulocytes are recruited to damaged tissues. READ MORE

  7. 5. Development of antimicrobial peptides : Methodological aspects, design, synthesis and evaluation of a new class of antimicrobial peptides

    Author : Marie Danielsson; Anders Undén; Maria Kempe; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : A new protective group for the indole nitrogen of the amino acid tryptophan, the Boc-sarcosinoyl-sarcosinolyl (Boc-Sar-Sar) is described. This protective group shows good stability to the reaction conditions used in solid phase peptide synthesis and can be incorporated into the peptide as Fmoc-Trp(Boc-Sar-Sar)-OH. READ MORE