Search for dissertations about: "bone marrow transplantation"

Showing result 16 - 20 of 139 swedish dissertations containing the words bone marrow transplantation.

2. 16. Development of Novel Models for Studying Osteoclasts

   Author : Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

   Abstract : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. READ MORE

4. 17. Targeting the hematopoietic stem cell to correct osteopetrosis

   Author : Carmen Flores Bjurström; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; bone marrow transplantation; gene therapy; osteoclasts; infantile malignant osteopetrosis;

   Abstract : This thesis focuses on developing stem cell targeted gene therapy for the severe hereditary disorder Infantile Malignant Osteopetrosis (IMO) as well as increasing the understanding of how the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a rare congenital disorder associated with an increased number of non-functional osteoclasts and the absence of bone resorption results in accumulation of sclerotic bone leading to abnormal bone marrow cavity formation insufficient to support hematopoiesis. READ MORE

5. 18. Posttransplant Lymphoproliferative Disorders : Studies of Epstein-Barr Virus, Regulatory T Cells and Tumor Origin

   Author : Amelie Kinch; Karlis Pauksens; Gunilla Enblad; Eva Baecklund; Harald Holte; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PTLD; Lymphoma; Epstein-Barr Virus; EBV DNAemia; FoxP3; Treg; Microenvironment; Cell of Origin; Recipient; Transplantation; Immunosuppression; Hepatitis C; Survival; Medicinsk vetenskap; Medical Science;

   Abstract : Epstein-Barr virus (EBV) infects almost all humans and establishes lifelong latency in B cells. Posttransplant lymphoproliferative disorder (PTLD) is a rare but serious complication after transplantation triggered by immunosuppression and often related to EBV infection. READ MORE

6. 19. Cytokine Regulation of Hematopoietic Stem Cells and Lymphopoiesis

   Author : Natalija Buza-Vidas; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; lineage commitment; cytokines; lymphopoiesis; extracellulära vätskor; transplantation; hematopoietic stem cells;

   Abstract : Large numbers of blood cells need to be continuously replaced in order to sustain the crucial functions of the immune system, oxygen transport and blood clotting. The large diversity of cell types required to maintain the integrity of the blood system are all produced from blood forming or hematopoietic stem cells (HSCs). READ MORE

7. 20. In vivo and in vitro evolution of molecular mechanisms - Importance in B cell development and phage display

   Author : Nina Nilsson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell development and phage display; transplantation; serology; Immunology; Immunologi; serologi; Biology; Biologi;

   Abstract : Bone marrow resident hematopoietic stem cells differentiate into all different types of lymphoid populations, there among mature naive B cells expressing IgM and IgD. During the maturation, the B cells are subjected to several steps of selection to ensure proper development of the antigen receptor. READ MORE