Search for dissertations about: "bone morphogenetic protein bmp"

Showing result 1 - 5 of 37 swedish dissertations containing the words bone morphogenetic protein bmp.

  2. 1. Craniofacial bone reconstruction with bone morphogenetic protein-2

    Author : Ann-Charlott Docherty Skogh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bone morphogenetic protein;

    Abstract : Bone defects in the craniofacial area are a clinical challenge and can be the result of trauma, tumour resection or congenital malformations. The golden standard for reconstruction is autologous bone grafts, but bone may not always be readily available and donor-site morbidity might follow. READ MORE

  4. 2. Molecular regulators in cartilage and bone formation

    Author : Thomas Engstrand; Uppsala universitet; []
    Keywords : Medical sciences; cartilage; bone; TGF-beta; BMP; noggin; gene therapy; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. READ MORE

  5. 3. The Anabolic - Anti-catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective

    Author : Neashan Mathavan; Avdelningen för Biomedicinsk teknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone fracture; Fracture healing; bone quality; Bone biomechanics; bone morphogenetic protein-7; Zoledronate; skeletal regeneration;

    Abstract : Successful fracture repair is a complex series of coordinated processes leading to regeneration of new bone to bridge the fracture site, remodelling of the newly formed bone and restoration of skeletal function. Disruption of these processes occurs in approximately 10% of all fractures and leads to delayed or failed healing requiring surgical interventions, increased complication rates, prolonged rehabilitation and high morbidity. READ MORE

  6. 4. Bone Enhancement with BMP-2 for Safe Clinical Translation

    Author : Marta Kisiel; Jöns Hilborn; Monica Wiig; Richard Oreffo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone repair; Bone healing; Bone morhogenetic protein-2; Osteogenesis; Extracelular matrix; Hyaluronan; Animal model; Orthopaedics; Ortopedi; Engineering Science with specialization in Materials Science; Teknisk fysik med inriktning mot materialvetenskap;

    Abstract : Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of bone regeneration. However, BMP-2 delivery in a conventional collagen scaffold needs a high dose to achieve an effective outcome. Moreover, such dosage may lead to serious side effects. READ MORE

  7. 5. Bone Regeneration with Cell-free Injectable Scaffolds

    Author : Gry Hulsart Billström; Sune Larsson; Kenneth B Jonsson; Jöns Hilborn; Håkan Engqvist; Olle Svensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone tissue engineering; hydrogel; computed tomography; positron emission tomography; large femoral bone defect; rat model; hydrogel; in vivo; osteogenesis; bone regeneration; 3R; single-photon emission computed tomography; bone morphogenetic protein 2; calcium phosphates; injectable; bisphosphonate;

    Abstract : Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Autologous bone grafting is commonly used throughout the world. READ MORE