Search for dissertations about: "bone-marrow-cells"

Showing result 1 - 5 of 49 swedish dissertations containing the word bone-marrow-cells.

  1. 1. Bactericidal/Permeability-Increasing Protein (BPI) and Proteinase 3: Studies at the Transcriptional Level

    Author : Katrien Pieters; Avdelningen för hematologi och transfusionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; azurophil granules; myelopoiesis; BPI; mouse ortholog; proteinase 3; transcriptional regulation; Wegener s Granulomatosis WG ; SNP; Medicine human and vertebrates ; extracellulära vätskor; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ;

    Abstract : In myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. READ MORE

  2. 2. Neuropeptides in bone and joint tissues : alteration in adjuvant arthitis

    Author : Adlan Mahmoud Elhassan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis, the localization, distribution and quantification of met-enkephalin (Met-enk), neurokinin-A and somatostatin in normal bone and joint tissues of the rat have been studied. Moreover, concentration alterations of these neuropeptides at the site of inflammation in the arthritic ankle joints as well as the spinal cords were evaluated. READ MORE

  3. 3. Studies of proteins in heme and iron metabolism

    Author : Vijole Dzikaite; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Iron; Heme; IRE IRP; Liver; eALAS; HFE;

    Abstract : One aim of the study was to investigate the regulation of the murine erythroid isoform of aminolevulinate synthase (eALAS) protein involved in heme synthesis. Another aim was to characterize the structure of the rat hemochromatosis gene (HFE) gene and its expression in conjunction with other genes involved in the regulation of iron homeostasis during inflammation and iron overload in the rat liver. READ MORE

  4. 4. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

    Author : Gösta Bergh; Helsingborg Kliniska Vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antisense; leukemia; cell cycle; differentiation; hematopoiesis; p16; p53; tumor suppressor genes; RB; oligonucleotides; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. READ MORE

  5. 5. The SHB adaptor protein in human and murine leukemia

    Author : Maria Jamalpour; Michael Welsh; Edvard Smith; Uppsala universitet; []
    Keywords : ;

    Abstract : The SHB adaptor protein operates downstream of tyrosine kinase receptors. It has been found previously that Shb deficiency in hematopoietic stem cells (HSCs) results in less proliferation and failure to maintain the myeloid compartment over time. READ MORE