Advanced search

Showing result 1 - 5 of 531 swedish dissertations matching the above criteria.

2. 1. Brain morphology and behaviour in the guppy (Poecilia reticulata) : Effects of plasticity and mosaic brain evolution

   Author : Stephanie Fong; Niclas Kolm; Björn Rogell; Stephen Montgomery; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; brain plasticity; cognition; reversal learning; spatial learning; directed selection; mosaic brain; heritability; brain morphology; boldness; relative telencephalon size; inhibitory control; detour task; Poecilia reticulata; etologi; Ethology;

   Abstract : Understanding how brains have evolved and subsequently culminated in the huge variation in brain morphology among contemporary vertebrate species has fascinated researchers for many decades. It has been recognized that brain morphology is both genetically and environmentally determined. READ MORE

4. 2. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

   Author : Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

5. 3. Imaging brain aromatase by using PET : A way to study anabolic steroid abuse

   Author : Kayo Takahashi; Mats Bergström; Bengt Långström; Yasuyoshi Watanabe; Torbjörn Bäckström; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aromatase; brain; molecular imaging; PET; [11C]Vorozole; amygdala; hypothalamus; anabolic-androgenic steroids; abuse; [18F]Vorozole analogs; Neuroscience; Neurovetenskap;

   Abstract : Aromatase is an enzyme that facilitates the conversion of androgens to estrogens and may play a role in mood and mental status. The main theme of this thesis is the imaging of brain aromatase by use of the PET technique. The PET tracer for aromatase, 11C-labeled vorozole (VOZ) was developed and evaluated by with in vitro and in vivo methods. READ MORE

6. 4. Human brain function evaluated with rCBF-SPECT : memory and pain related changes and new diagnostic possibilities in Alzheimer’s disease

   Author : Torbjörn Sundström; Katrine Riklund; Rimma Danielsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain imaging; rCBF; SPECT; early diagnosis; brain atlas; HMPAO; Alzheimer´s disease; Whiplash; neuropsychological function; episodic memory; Diagnostic radiology; Diagnostisk radiologi;

   Abstract : The aim of this doctoral thesis was to study the influence of memory, pain, age and education on the regional cerebral blood flow (rCBF), i.e. brain function, in early Alzheimer's disease (AD) and in chronic neck pain patients in comparison to healthy controls and in healthy elderly per se. READ MORE

7. 5. Social Phobia. From Epidemiology to Brain Function

   Author : Tomas Furmark; Uppsala universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; Anxiety; brain; epidemiology; fear; neuroimaging; neurotransmitters; positron emission tomography; prevalence; serotonin; social phobia; subtypes; treatment; Psykologi; Psychology; Psykologi; Psychology; psykologi;

   Abstract : Social phobia is a disabling anxiety disorder characterized by an excessive fear of negative evaluation in social situations. The present thesis explored the epidemiology and neurobiology of the disorder. By means of a mailed questionnaire, the point prevalence of social phobia in the Swedish general population was estimated at 15.6%. READ MORE