Search for dissertations about: "brain stem"

Showing result 1 - 5 of 260 swedish dissertations containing the words brain stem.

  2. 1. Brain Stem Involvement in Immune and Aversive Challenge

    Author : Jakob Paues; Anders Blomqvist; Finn Hallböök; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipopolysaccharide; Lithium Chloride; anorexia; aversion; parabrachial; brain stem; melanocortin; CGRP; enkephalin; Neurobiology; Neurobiologi;

    Abstract : Activation of the immune system by e.g. bacteria induces the acute-phase-response and sickness behaviour. The latter encompasses among other things fever, lethargy, anorexia and hyperalgesia. READ MORE

  4. 2. Stem cell based therapy of malignant brain tumors

    Author : Daniel Bexell; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; pericyte; mesenchymal stem cell; neuroblast; subventricular zone; cancer stem cell; rat; glioma; cancer;

    Abstract : Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. READ MORE

  5. 3. Brain Regeneration - in vitro and in vivo studies of exercise-related effects on brain plasticity

    Author : Cecilia Bull; Göteborgs universitet; []
    Keywords : brain; neural progenitor cells; stem cells; hippocampus; corpus collosum; rat; mouse; regeneration; neurogenesis; oligodendrogenesis; irradiation; exercise;

    Abstract : Neural stem and progenitor cells in the germinal regions of the adult brain, such as the hippocampus, are of great interest, because they provide the possibility for enhanced brain plasticity or can contribute to endogenous cell replacement after injury or disease. Voluntary exercise was recently shown to robustly induce cellular and structural plasticity, thereby contributing to overall brain health. READ MORE

  6. 4. Modeling glioblastoma heterogeneity to decipher its biology

    Author : Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

    Abstract : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. READ MORE

  7. 5. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

    Author : Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

    Abstract : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. READ MORE