Search for dissertations about: "brain tumor development"

Showing result 1 - 5 of 126 swedish dissertations containing the words brain tumor development.

2. 1. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

   Author : Anqi Xiong; Karin Forsberg Nilsson; Joanna Phillips; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; medulloblastoma; neural stem cell; heparanase; NRBP2; dog models; susceptibility;

   Abstract : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. READ MORE

4. 2. Heparan Sulfate Proteoglycans in Brain Tumor Development

   Author : Argyris Spyrou; Karin Forsberg Nilsson; Fredrik Johansson Swartling; Jöns Hilborn; John Couchman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; pediatric brain tumors; heparanase; NDST1; heparan sulfate proteoglycans; CD24; glycosaminoglycan mimetics; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Abstract : Malignant brain tumors are aggressive neoplasms that remain challenging to treat in spite of their detailed molecular characterization. Both adults and children may suffer from brain tumors, which, if not lethal, can cause severe long-term and devastating side effects. READ MORE

5. 3. Beyond Survival - Cognition after Pediatric Brain Tumor

   Author : Ingrid Tonning Olsson; Lund Pediatrik; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Pediatric Brain Tumor; Cognition; Late sequelae; Cranial Radiation Therapy; Neuropsychology;

   Abstract : Background: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. READ MORE

6. 4. Screening for Candidate Brain Tumor Genes : Identifying Genes that Cooperate with Platelet-Derived Growth Factor in Glioma Development and Progression

   Author : Fredrik Johansson; Bengt Westermark; Leif Carlsson; Uppsala universitet; []
   Keywords : Pathology; PDGF; insertional mutagenesis; retroviral tagging; common insertion site; glioma; expression; cGMP-dependent protein kinase II; Patologi;

   Abstract : Malignant primary brain tumors, gliomas, often overexpress both platelet-derived growth factor (PDGF) ligands and receptors providing an autocrine and/or paracrine boost to tumor growth. Glioblastoma multiforme (GBM) is the most frequent glioma. Its aggressive and infiltrative growth renders it extremely difficult to treat. READ MORE

7. 5. Brain development in a dish

   Author : Robin Johan Pronk; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis shows the path I took in the quest for modeling the brain, as the title says, in a dish. The introduction of induced pluripotent stem cells (iPSCs) as means to research biological processes has opened up whole new fields of study and unprecedented possibilities of generating human cells in vitro. READ MORE