Search for dissertations about: "brain-derived neurotrophic factor"

Showing result 1 - 5 of 70 swedish dissertations containing the words brain-derived neurotrophic factor.

  1. 1. Brain-derived neurotrophic factor in cerebral ischemia: a quantitative study on surviving and newly formed neurons

    Author : Elin Gustafsson; Lund Klinisk fysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain-derived neurotrophic factor; cerebral ischemia; neuronal survival; neurogenesis; hippocampus; striatum; immunocytochemistry; stereology; neuropsykologi; Neurologi; neurophysiology; neuropsychology; neurofysiologi; Neurology;

    Abstract : This study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i. READ MORE

  2. 2. Brain-derived neurotrophic factor and endocannabinoid functions in gabaergic interneuron development

    Author : Paul Berghuis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Formation of the cerebral cortex is controlled by tightly regulated processes: the proliferation and survival decisions of neural progenitors, radial and tangential migration of neuronal precursors, axon guidance and dendritic growth underpinning the formation of synapses. Patterning of the neocortex has been extensively studied and significant progress has been made in understanding the principles of cortical neuronal circuit formation. READ MORE

  3. 3. Role of the brain derived neurotrophic factor and inflammatory mediators in colon cancer

    Author : Syrina Mehrabi; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colon Cancer; Neutrophils; Inflammation; CysLT1R; BDNF; Tumor microenvironment; Prognostic; Predictive; Diagnostic; Gene signature; Biomarkers;

    Abstract : CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18. READ MORE

  4. 4. Antidepressive and antipsychotic treatments : Effects on nerve growth factor and brain-derived neurotrophic factor in rat brain

    Author : Francesco Angelucci; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Recently it has been reported that depression and schizophrenia, the two major psychiatric disorders, are characterized by loss of neurons in specific brain regions. Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are proteins involved in neuronal survival and plasticity of dopaminergic, cholinergic and serotonergic neurons in the central nervous system (CNS). READ MORE

  5. 5. On pathophysiological mechanisms in amyothrophic lateral sclerosis

    Author : Eva Grundström; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Amyotrophic lateral sclerosis; ALS; spinal cord; motor neuron; cerebrospinal fluid; CSF; muscle; glial cell line-derived neurotrophic factor; GDNF; brain- derived neurotrophic factor; BDNF; ACh; vesamicol; apoptosis; Bax; Bcl-2; neurodegeneration; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Abstract : Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disease with unknown ethiology. The aim of this study was to increase understanding of the pathophysiological mechanisms of dying motor neurons and wasting muscle tissue in this particular disorder. READ MORE