Search for dissertations about: "brain-derived neurotrophic factor"

Showing result 11 - 15 of 73 swedish dissertations containing the words brain-derived neurotrophic factor.

  2. 11. Neurotrophic factors and neuronal plasticity

    Author : Sten Linnarsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The neurotrophic factors were originally discovered because of their ability to rescue neurons during a period of naturally occurring programmed cell death. This gave rise to the neurotrophic factor hypothesis which states that specific target-derived factors protect and support subpopulations of innervating neurons, thereby regulating the pattern and quantity of innervation properly for each target tissue. READ MORE

  4. 12. A Muscle Perspective on the Pathophysiology of Amyotrophic Lateral Sclerosis : Differences between extraocular and limb muscles

    Author : Vahid M. Harandi; Jingxia Liu; Fatima Pedrosa Domellöf; Per Stål; Fawzi Kadi; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuromuscular junctions; Extraocular muscles; Skeletal muscle; Neurotrophic factor; Wnt; Motor neuron disease; Amyotrophic lateral sclerosis; SOD1G93A mice; molekylärbiologi; Molecular Biology;

    Abstract : Background: Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disorder. ALS has been traditionally believed to be primarily a motor neuron disease. READ MORE

  5. 13. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms

    Author : Mikael Ryden; Karolinska Institutet; Karolinska Institutet; []
    Keywords : neurotrophins; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; p75 neurotrophin receptor; neuroblastoma; serinethreonine kinase receptors;

    Abstract : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. READ MORE

  6. 14. Neurotrophic and immune regulatory factors in neuroinflammation

    Author : Alexander W Gielen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Neurotrophins; EAE; MS; TIM; Neuroprotection;

    Abstract : Inflammatory reactions in the nervous system act as a double-edged sword. On the one hand, neuroinflammation can have very devastating effects on the nervous system, leading to neurological dysfunction. READ MORE

  7. 15. On functions of neurotrophic factors in taste buds and teeth

    Author : Irina Vukmanovic Nosrat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Chemosensory disorders affect approximately 15% of the U.S. population and an estimated 200,000 individuals visit a doctor each year for problems with their ability to taste or smell (NIDCD). READ MORE