Search for dissertations about: "breast cancer and chemotherapy"

Showing result 1 - 5 of 93 swedish dissertations containing the words breast cancer and chemotherapy.

  2. 1. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Author : Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Abstract : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. READ MORE

  4. 2. Neoadjuvant chemotherapy in muscle-invasive urinary bladder cancer : studies on treatment response, tumor draining lymph nodes and blood transfusion

    Author : Robert Rosenblatt; Amir Sherif; Ola Winqvist; Per Marits; Ralph Peeker; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bladder cancer; neoadjuvant chemotherapy; tumor downstaging; sentinel nodes; blood transfusion; Urology; kirurgi; särskilt urologi; Medicine; medicin;

    Abstract : Muscle-invasive urinary bladder cancer is a deadly disease. Mortality rates remained unchanged for decades despite radical surgery.After several randomized trials, we today know that cisplatin based chemotherapy given prior to cystectomy, improves survival for every tenth patient. READ MORE

  5. 3. The proteasome as a target for cancer therapy

    Author : Peter Larsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Cell viability assay; Chemotherapy; Drug repurposing; Genomic and transcriptomic signatures; Prognostic biomarkers; Proteasome; Proteasome genes; Proteasome inhibitors; Drug sensitivity biomarkers; Synergistic effect; Triple-negative breast cancer;

    Abstract : The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The proteasome (PSM) plays an important role in maintaining cellular proteostasis and degrades the majority of proteins that require breakdown in the cell. READ MORE

  6. 4. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Author : Slavica Janeva; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Abstract : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. READ MORE

  7. 5. Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine

    Author : Emma Niméus; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 2-DE; cyclin B1; breast cancer; radioresistance; immunohistochemistry; chemotherapy resistance; gene expression; treatment prediction; prognosis;

    Abstract : Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. READ MORE