Search for dissertations about: "breast cas9"

Showing result 1 - 5 of 6 swedish dissertations containing the words breast cas9.

  2. 1. A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer

    Author : Huan He; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy resistance. READ MORE

  4. 2. A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1) in cancer

    Author : Dandan Song; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Activator protein-1 (AP-1) is a transcriptional factor complex that mainly consists of Fos and Jun family members. Jun proteins can form both homodimers and heterodimers, whereas Fos family members only form heterodimers with the Jun family. Fra-1 is a member of the Fos family proteins and plays a vital role in breast cancer progression. READ MORE

  5. 3. Novel methods to study genomic fragility and structural variation

    Author : Reza Mirzazadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : DNA double-strand breaks (DSBs) are major DNA lesions that when repaired unfaithfully can give rise to loss of genetic information, chromosomal rearrangements such as insertions/deletions (indels) and copy number alterations (CNAs), which in turn lead to genomic instability that is characteristic of almost all cancer types. In this context, it is thought that genomic instability has critical roles in cancer initiation, progression and intra-tumor heterogeneity (ITH). READ MORE

  6. 4. Role of TGFβ-induced hyaluronan-CD44 signaling in cancer progression

    Author : Constantinos Kolliopoulos; Evi Heldin; Aristidis Moustakas; Jonathan Sleeman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hyaluronan; CD44; TGFβ; cancer; EMT; signal transduction; transcriptional regulation;

    Abstract : Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathological conditions, such as chronic inflammation, infection, and cancer. Hyaluronan synthase HAS2 has been responsible for the synthesis and deposition of hyaluronan in a variety of tumors. READ MORE

  7. 5. Developing methods for mapping genetic heterogeneity in tumors : from bulk to single-cell resolution

    Author : Michele Simonetti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tumors are complex ecosystems composed of billions of cells that constantly evolve over time. Intra-tumor heterogeneity (ITH) represents the diversity of this complex environment quantifiable both at the genetic and phenotypic level. Recently, next-generation sequencing (NGS) costs have dropped and NGS has become the standard tool for studying ITH. READ MORE