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Showing result 1 - 5 of 138 swedish dissertations matching the above criteria.

  2. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

    Author : Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
    Keywords : breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

    Abstract : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). READ MORE

  4. 2. Expression and function of vascular estrogen receptors alpha and beta

    Author : Min Liang; Kärlfysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetologi; diabetology; Endokrinologi; sekretion; ubiquitin-proteasome pathway; MIP-2; MCP-1; iNOS; estrogen receptor knockout; estrogen receptor; aorta; estrogen;

    Abstract : Estrogen receptors (ER) are expressed not only in classical target organs for estrogen like breast and uterus, but also in male reproductive system as well as in non-reproductive organs such as brain, liver and bone. The functions of ER are quite well known in reproductive organs but less information is available regarding their function in vascular tissue. READ MORE

  5. 3. Erythropoietin receptor in growth control and anti-estrogen resistance of estrogen receptor positive breast cancer

    Author : Susann Reinbothe; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tamoxifen resistance; proliferation; PI3k pathway; Breast cancer; erythropoietin receptor; estrogen receptor;

    Abstract : The main function of Erythropoietin (EPO) and its receptor (EPOR) is the stimulation of erythropoiesis. Therefore, recombinant human EPO (rhEPO) is used to treat anemia in cancer patients, but some studies have reported that rhEPO treatment might promote tumor progression. Additionally, EPOR expression has been detected in various cancer forms. READ MORE

  6. 4. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

    Author : Karolina Helczynska; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

    Abstract : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. READ MORE

  7. 5. Estrogen receptor alpha and beta in breast cancer - gene expression profiles and clinical implications

    Author : Sofia Gruvberger; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; artificial neural networks; gene expression profiling; microarray; tamoxifen; adjuvant endocrine therapy; ER; estrogen receptor beta; Breast cancer; estrogen receptor alpha; Clinical biology;

    Abstract : Breast cancer is the most common malignancy in women in the Western world with about 10% of women developing breast cancer during their lifetime, of which one third will eventually succumb to the metastatic form of the disease. Breast cancer arises from the epithelial cells of the breast mammary gland, but the mechanisms involved in tumor initiation, progression, and metastasis are still not fully understood. READ MORE