Search for dissertations about: "breast estrogen"

Showing result 11 - 15 of 138 swedish dissertations containing the words breast estrogen.

  2. 11. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

    Author : Maria Gebre-Medhin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

    Abstract : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. READ MORE

  4. 12. Clinical significance of immunohistochemistry in breast cancer diagnostics

    Author : Slavica Janeva; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer biomarkers; immunohistochemistry; surrogate subtype; RT- qPCR; multifocal breast cancer; lymph node metastasis; triple-negative breast cancer; older women;

    Abstract : For patients with breast cancer, modern patient-tailored treatment depends on tumor- specific characteristics, i.e., estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), and the proliferation marker Ki67. READ MORE

  5. 13. Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer

    Author : Åsa Kronblad; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; General pathology; breast cancer; hypoxia; cyclin D1; Cytology; oncology; estrogen receptor; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Abstract : Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the receptor. READ MORE

  6. 14. Function of Innate Immune Cells in Breast Cancer

    Author : Fríða Björk Gunnarsdóttir; Malmö Cancerimmunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor associated macrophages; Breast cancer; Estrogen receptor alpha; FOXO3a; CD169; PD-L1; metastatic lymph node;

    Abstract : Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. READ MORE

  7. 15. Genetic determinants of breast cancer risk

    Author : Jingmei Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast Neoplasms;

    Abstract : The main purpose of this thesis was to identify genetic risk factors using both hypothesis-based and hypothesis-free approaches. In an attempt to identify common disease susceptibility alleles for breast cancer, we started off with a hypothesis-free approach, and performed a combined analysis of three genome-wide association studies (GWAS), involving 2,702 women of European ancestry with invasive breast cancer and 5,726 controls. READ MORE