Search for dissertations about: "breast estrogen"

Showing result 16 - 20 of 138 swedish dissertations containing the words breast estrogen.

2. 16. Reproductive factors with respect to breast cancer risk and breast cancer survival

   Author : Mohammadhossein Hajiebrahimi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Breast cancer;

   Abstract : Aims: The primary aim of this thesis was to examine the potential relationship between indirect markers of exposure to hormones during pregnancy and the risk of and survival from breast cancer, with special emphasis on young patients. Our specific objectives were as follows: to determine whether the association between placental weight and offspring size, on the one hand, and maternal mortality from breast cancer, on the other, are influenced by tumor characteristics; to examine the association between birth weight and risk of breast cancer in the female member of opposite-sexed twins; and to investigate whether familial factors influence previously reported association between reproductive factors and risk of breast cancer. READ MORE

4. 17. MicroRNAs in HER2-Amplified Breast Cancer

   Author : Inga Newie; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miR-21; PAPD5; Breast Cancer; miR-4728; microRNA; ERBB2 HER2;

   Abstract : Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. READ MORE

5. 18. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

   Author : Sophie Lehn; Malmö Molekylär patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; subgroups; proliferation; migration; stem cells; tamoxifen; estrogen receptor;

   Abstract : Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. READ MORE

6. 19. Breast cancer in young women. Aspects of heredity and contralateral disease

   Author : Annelie Augustinsson; LUCC: Lunds universitets cancercentrum; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer;

   Abstract : Breast cancer is the most commonly diagnosed cancer among women in Sweden, as well as worldwide. In Sweden, 8,288 women were diagnosed with invasive breast cancer in 2019, out of whom approximately 1.5% were younger than 35 years of age. READ MORE

7. 20. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

   Author : Anna-Maria Larsson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Anemia; Hypoxia; Erythropoietin EPO ; EPO receptor EPOR ; Estrogen Receptor ER ; Hypoxia-Inducible Factors HIFs ; Tamoxifen Response; Proliferation;

   Abstract : The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. READ MORE