Search for dissertations about: "brunn"

Found 4 swedish dissertations containing the word brunn.

  2. 1. Approaches to Optimizing High Content Confocal Microscopy

    Author : Erland Lewin; Hjalmar Brismar; Kjell S. Carlsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis presents two methods for improving high contentconfocal microscopy.The author's part in the first, "Toward a confocal subcellular atlasof the human proteome" was automating image capture of foursimultaneously tagged structures in cells in 96 well plates. In total,thousands of images of hundreds of proteins in cells. READ MORE

  4. 2. Ligand-based Methods for Data Management and Modelling

    Author : Jonathan Alvarsson; Jarl E. S. Wikberg; Ola Spjuth; Claes Andersson; Martin Eklund; John P. Overington; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QSAR; ligand-based drug discovery; bioclipse; information system; cheminformatics; bioinformatics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology; Bioinformatik; Bioinformatics;

    Abstract : Drug discovery is a complicated and expensive process in the billion dollar range. One way of making the drug development process more efficient is better information handling, modelling and visualisation. The majority of todays drugs are small molecules, which interact with drug targets to cause an effect. READ MORE

  5. 3. Heterogeneity-Induced Channelling, Flow-Wetted Surface, and Modelling of Transport in Fractured Rock

    Author : Martin Larsson; Auli Niemi; Chin-Fu Tsang; VLADIMIR CVETKOVIC; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; channelling; flow-wetted surface; fractured rock; solute transport; groundwater modelling; groundwater; Hydrology; Hydrologi;

    Abstract : Heterogeneities in fractured rock are found at all scales; from the scale of individual fractures, to the scale of fracture networks, and to the largest regional scales. These heterogeneities cause challenges for modelling and parameter estimation of flow and solute transport. READ MORE

  6. 4. Intestinal Bypass and Total Parenteral Nutrition: Changes in Gut Function and Morphology

    Author : Mikael Ekelund; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; Gastroenterologi; Gastro-enterology; Fysiologi; Physiology; total parenteral nutrition; supersensitivity; plasticity; intestinal bypass; interstitial cells of Cajal; goblet cells; eosinophils; adaptation; enteric nervous system;

    Abstract : Abolition of enteral nutrition is sometimes required in severe illness. The primary aim of the present work has been to elucidate possible changes in intestinal morphology and motor function in absence of enteral nutrition. Total absence of enteral nutrition in an isolated intestinal segment was created by bypassing the distal ileum in a rat model. READ MORE