Search for dissertations about: "burkitt"

Showing result 1 - 5 of 39 swedish dissertations containing the word burkitt.

  1. 1. Burkitt lymphoma and diffuse large B-cell lymphoma – therapeutic strategies and pathogenetic mechanisms

    Author : Tove Wästerlid; Tumörmikromiljö; []
    Keywords : Burkitt Lymphoma; Chemotherapy; SOX11; Diffuse large B-cell lymphoma; Prognostic factors; Rituximab;

    Abstract : Burkitt lymphoma (BL) is a rare, aggressive disorder constituting 1% of all non-Hodgkin lymphoma. Diffuse large B-cell lymphoma (DLBCL) is more common, accounting for 30% of malignant lymphoma. Standard treatment for adult BL and for certain subgroups of patients with DLBCL remains to be defined due to paucity of randomised trials performed. READ MORE

  2. 2. Malaria, B lymphocytes and Epstein-Barr virus : Emerging concepts on Burkitt´s lymphoma pathogenesis

    Author : Daria Donati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Malaria; Plasmodium falciparum; B lymphocytes; polyclonal activation; hypergammaglobulenemia; EpsteinBarr virus; endemic Burkitt s lymphoma.;

    Abstract : Plasmodium falciparum and Epstein-Barr virus (EBV) infections are recognized co-factors in the genesis of endemic Burkitt's Lymphoma (eBL), the most common paediatric cancer in equatorial Africa. This thesis work examines and discusses interactions between Pfalciparum and EBV that could promote the emergence of eBL. READ MORE

  3. 3. Role of latent EBV genes in the induction of genomic instability in Burkitt s lymphoma

    Author : Bettina Gruhne; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. READ MORE

  4. 4. p53 inactivation by point mutations and splice site mutations in human and mouse tumors

    Author : Kristinn P. Magnússon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; p53; Burkitt Iymphoma; apoptosis; alternative splicing; mutation; ascites;

    Abstract : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. READ MORE

  5. 5. Characteristics of EBV-infected B cell lines and B-CLL clones which determine their interaction with lymphocytes

    Author : Javier Federico Avila-Carino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; EBV; Burkitt Iymphoma; CLL; MLC; antiviral response phenotype; cytokines.;

    Abstract : CHARACTERISTICS OF EBV-INFECTED B CELL LINES AND B-CLL CLONES WHICH DETERMINE THEIR INTERACTION WITH T LYMPHOCYTES Javier Federico Avila-Cariho Doctoral dissertation from the Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden The results concerning T Iymphocyte mediated recognition of Epstein-Barr virus (EBV) carrying Burkitt Iymphoma (BL) cell lines and EBV-infected chronic Iymphocytic leukemia (CLL) B cells contribute to the understanding of the generally harmless host-EBV interaction and may be extrapolated to the fate of normal B cells after EBV infection. The phenotype of EBV negative BL lines resembles resting B cells. READ MORE