Search for dissertations about: "burkitt"
Showing result 21 - 25 of 38 swedish dissertations containing the word burkitt.
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21. Role of latent EBV genes in the induction of genomic instability in Burkitt’s lymphoma
Abstract : Epidemiological and molecular evidence link Epstein-Barr virus (EBV) infection to a variety of lymphoid and epithelial malignancies but the contribution of the virus to tumorigenesis is unclear. Genomic instability, defined by the establishment of a mutator phenotype and characterized by the occurrence of non-clonal chromosomal aberrations, excessive DNA damage and defects in DNA repair, is the hallmark of malignant transformation. READ MORE
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22. Estrogens and lymphoma growth
Abstract : Lymphomas are generally not considered as endocrine-associated cancers. Nevertheless, most lymphoid malignancies show a gender differencein incidence and prognosis, with males being more affected.The molecular mechanism for this gender difference is unknown. READ MORE
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23. Identification and functional characterization of Epstein-Barr virus-encoded deconjugases
Abstract : The post-translational conjugation or deconjugation of proteins by ubiquitin (Ub) or ubiquitin-like molecules (UbLs: e.g. SUMO, NEDD8, ISG15) has emerged as a major regulatory mechanism of various cellular activities. READ MORE
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24. Examining the role of metabolism in Myc-driven tumorigenesis
Abstract : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis. MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. READ MORE
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25. The impact of microenvironmental factors on EBV carrying B cells
Abstract : Epstein-Barr virus (EBV) is a human gamma-herpes virus that colonized more than 90% of the adult population. The virus is able to infect and immortalize B lymphocytes both in vitro and in vivo. READ MORE