Search for dissertations about: "c-Jun"

Showing result 16 - 20 of 71 swedish dissertations containing the word c-Jun.

  2. 16. Transcriptional regulation of the latent membrane protein 1 gene by Epstein-Barr virus nuclear antigen 2

    Author : Lars Palmqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; EBNA2; transcription; phosphorylation; histone acetylation;

    Abstract : The Epstein-Barr virus (EBV) is a ubiquitous human herpes virus, which infects B-cells. This leads to a life-long latent infection, which in most cases is non-pathogenic. However, EBV is etiologically associated with several human malignancies, including endemic Burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoma. READ MORE

  4. 17. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

    Author : Ulrik Fried; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

    Abstract : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. READ MORE

  5. 18. Expression and regulation of vasoactive substances, sex steroids and their receptors in placenta during normal pregnancy and preeclampsia

    Author : Josefine Nasiell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite intense studies preeclampsia remains enigmatic and a major cause of maternal and fetal morbidity and mortality. It is now widely accepted that the placenta has a central role in preeclampsia; delivery of the placenta is the only known cure. READ MORE

  6. 19. A multi-omics approach to uncover estrogen receptor (ER) and activator protein 1 (AP-1) signaling networks in breast cancer

    Author : Huan He; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen receptor (ER) binds to DNA indirectly through other transcription factors (e.g. AP-1) to modulate gene expression, which is a tethering mechanism. The ER/AP-1 crosstalk plays an important role in tamoxifen therapy resistance. READ MORE

  7. 20. Intracellular mechanisms in rd1 mouse retinal degeneration

    Author : Leif Johnson; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ophtalmology; Neuroprotection; Photoreceptor; Retinitis Pigmentosa; Oftalmologi;

    Abstract : Retinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. READ MORE