Search for dissertations about: "c-Kit"
Showing result 1 - 5 of 40 swedish dissertations containing the word c-Kit.
-
1. Receptor tyrosine kinase c-Kit signalling in hematopoietic progenitor cells
Abstract : The receptor tyrosine kinase (RTK) c-Kit is expressed in hematopoietic stem and progenitor cells, mast cells and in several non-hematopoietic tissues. In the hematopoietic system c-Kit and its ligand Steel Factor (SF, aka Stem Cell Factor) are critical for proliferation, survival and differentiation. READ MORE
-
2. Maintenance and Commitment of Hematopoietic Progenitors: Role of flt3, c-kit and c-mpl
Abstract : The need for red blood cells to transport oxygen and CO2, blood platelets to stop bleedings, and neutrophils, macrophages, B- and T-cells for host defense, is a prerequisite for life. These mature blood cells have a limited life span and are thus constantly replenished by an enormous cell production (estimated to 1012 cells per day) which primarily takes place in the bone marrow (BM). READ MORE
-
3. New Diagnostic and Therapeutic Approaches in Adrenocortical Cancer
Abstract : Adrenocortical cancer (ACC) is a rare disease that is often difficult to diagnose, and therefore often presents at an advanced stage. Various cytotoxic treatments have been tried with little success. Evaluation of new diagnostic methods and improvement of medical therapies are therefore crucial. READ MORE
-
4. Identification and characterization of progenitor populations in the human adult heart
Abstract : Traditionally, the heart has been regarded as a non-regenerative organ. During the last 10 years, this notion has been challenged. By 14C measurements, it was calculated that at the age of 50, about 45% of all cardiomyocytes had formed after birth. READ MORE
-
5. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells
Abstract : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. READ MORE