Search for dissertations about: "cAMP PKA system"

Showing result 1 - 5 of 17 swedish dissertations containing the words cAMP PKA system.

  2. 1. Regulation of E-cadherin mediated adhesion in thyroid epithelial cells

    Author : Fredrik Larsson; Göteborgs universitet; []
    Keywords : thyroid; adherens junction; E-cadherin; thyrotropin; cAMP; PKA; Epac; IQGAP;

    Abstract : Cell adhesion is one of multicellular organisms most fundamental features. Cells connect to each other by transmembrane proteins arranged in junction complexes. READ MORE

  4. 2. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

  5. 3. The impact of glucotoxicity on pancreatic β-cell function

    Author : Sarheed Jabar Muhammed; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE

  6. 4. Protein kinases in hormonal regulation of adipocyte metabolism

    Author : Christine Berggreen; Proteinfosforylering; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Abstract : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. READ MORE

  7. 5. Role of the dopamine system in motor skill learning : implications for neurodevelopmental disorders

    Author : Yu Qian; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Dopamine (DA), released by midbrain neurons, is critical for motor performance, motor skill learning, and corticostriatal synaptic plasticity. Dysregulation of DAergic signaling in corticostriatal circuitry has also been implicated in several highly heritable neurodevelopmental disorders, such as attention/deficit hyperactivity disorder (ADHD), which are often associated with deficits in fine motor skills. READ MORE