Search for dissertations about: "cDNA microarray"

Showing result 11 - 15 of 55 swedish dissertations containing the words cDNA microarray.

2. 11. Global Profiling of Host Cell Gene Expression During Adenovirus Infection

   Author : Fredrik Granberg; Hongxing Zhao; Ulf Pettersson; Richard Roberts; Uppsala universitet; []
   Keywords : Genetic engineering; Adenovirus; Microarray; Gene expression; Host-virus interaction; Genteknik;

   Abstract : To investigate mechanisms involved in virus-host interactions, global changes in host gene expression were examined during infection with adenovirus type 2 (Ad2) using cDNA microarray technology. In paper I and II, transcriptional changes in HeLa cells were investigated during the early and late phase of infection, respectively. READ MORE

4. 12. Transcriptome analysis on in vivo derived laser microbeam microdissected cells. Analysis of smooth muscle transcriptomes

   Author : Stefan Johannes Scheidl; Göteborgs universitet; []
   Keywords : microarray; laser microdissection; RNA amplification; smooth muscle cells; smooth muscle differentiation; smooth muscle transcriptome; smooth muscle diversity;

   Abstract : Smooth muscle cells (SMCs) are found in the respiratory, urogenital, circulatory and digestive systems. They provide contractility and structural support for those organs and perform multiple physiological important functions, such as modulation of blood pressure, regulation of airway resistance, and control of gastrointestinal and genitourinary motility. READ MORE

5. 13. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

   Author : Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

   Abstract : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). READ MORE

6. 14. Estrogen receptor alpha and beta in breast cancer - gene expression profiles and clinical implications

   Author : Sofia Gruvberger; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; oncology; cancerology; Cytologi; onkologi; cancer; Cytology; artificial neural networks; gene expression profiling; microarray; tamoxifen; adjuvant endocrine therapy; ER; estrogen receptor beta; Breast cancer; estrogen receptor alpha; Clinical biology;

   Abstract : Breast cancer is the most common malignancy in women in the Western world with about 10% of women developing breast cancer during their lifetime, of which one third will eventually succumb to the metastatic form of the disease. Breast cancer arises from the epithelial cells of the breast mammary gland, but the mechanisms involved in tumor initiation, progression, and metastasis are still not fully understood. READ MORE

7. 15. RhoGTPase Signaling in Cell Polarity and Gene Regulation

   Author : Ann-Sofi Johansson; Pontus Aspenström; Johan Lennartsson; Christer Larsson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RhoGTPase; Par6; cell polarity; aPKC; epithelial cell; PDGF; gene regulation; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. READ MORE