Search for dissertations about: "cGMP"

Showing result 1 - 5 of 57 swedish dissertations containing the word cGMP.

  1. 1. The potential role of retinal cGMP-interaction partners within the degeneration mechanism causing Retinitis Pigmentosa

    Author : Michel Rasmussen; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Retinitis Pigmentosa; Photoreceptors; cGMP; cGMP-interactors; retinal degeneration; neuroprotection;

    Abstract : The eye disease Retinitis Pigmentosa (RP) represents a heterogeneous group of inherited retinal dystrophies, and it has been estimated that 1 in 3000 to 7000 people worldwide has the disease. The symptoms of RP are photoreceptor degeneration that leads to night blindness, followed by a decline in peripheral and central vision, and potential blindness. READ MORE

  2. 2. Genes and proteins controlled by cGMP-PKG during retinal degeneration

    Author : Jiaming Zhou; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

    Abstract : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. READ MORE

  3. 3. The prefrontal cortex and information processing : nitric oxide signaling studied in an animal model of schizophrenia

    Author : Kim Fejgin; Göteborgs universitet; []
    Keywords : schizophrenia; nitric oxide; prepulse inhibition; phencyclidine; prefrontal cortex; cGMP; baclofen; cognition;

    Abstract : The prefrontal cortex has been extensively linked to several cognitive domains that are severely compromised in schizophrenia. It has therefore become a key region for studies on the disabling cognitive dysfunction commonly observed in patients with schizophrenia. READ MORE

  4. 4. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

  5. 5. Muscarinic receptors and cGMP synthesis : studies on human and rat tissues

    Author : Erik Danielsson; Stockholms universitet; []

    Abstract : .... READ MORE