Search for dissertations about: "cGMP"

Showing result 11 - 15 of 57 swedish dissertations containing the word cGMP.

2. 11. Nutrient and energy sensing in skeletal muscle

   Author : Atul S Deshmukh; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Skeletal muscle; AMPK; mTOR; glucose metabolism; exercise; Akt; TBC1D1 D4; CaMK; NO-cGMP;

   Abstract : Nutrient overload and physical inactivity often leads to the development of obesity and type 2 diabetes. Acute over-nutrition can induce insulin resistance, while physical exercise enhances skeletal muscle insulin sensitivity. Like every living cell, skeletal muscle senses nutrient and energy signals and to adjust metabolic flux. READ MORE

4. 12. Human ovarian follicles and oocytes : collection, cryopreservation, culture and gene expression

   Author : Pu Zhang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Ovarian follicle; oocyte; follicular aspirate; organ culture; cAMP; cGMP; cryopreservation; microarray; human gene expression; embryonic stem cell; preimplantation;

   Abstract : Infertility affects approximately 15% of couples globally. The most effective treatment today is in vitro fertilization. However, not all couples can be helped with the current techniques. To achieve better success, techniques of storage and in vitro maturation of ovarian follicles have to be improved. READ MORE

5. 13. Nerve-induced release of nitric oxide in gastrointestinal and erectile tissue

   Author : Katarina Hallén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Autonomic neurotransmission; cyclic guanosine monophosphate; guinea pig colon; neuronal nitric oxide synthase; nitric oxide; nitrite; phosphodiesterase; rabbit corpus cavernosum; smooth muscle; soluble guanylate cyclase;

   Abstract : Nitric oxide (NO) is an important messenger of the autonomic nervous system, innervating the gastrointestinal and urogenital tracts among many other tissues. The aim of the present thesis was to study the nitrergic neurotransmission in enteric and erectile tissue with special emphasis on modulation of nitrergic neurotransmission by the soluble guanylate cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-pathway. READ MORE

6. 14. Signal transduction and calcium sensitivity of smooth muscle contraction

   Author : Johan Bonnevier; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; hypertrophy; CPI-17; MYPT1; myosin phosphatase; Rho kinase; PKC; smooth muscle; cGK;

   Abstract : Smooth muscles are components of several physiologically important organs and often involved in disease. Smooth muscle contraction is regulated by variations in intracellular [Ca2+]; increased levels activate the myosin light chain kinase (MLCK) which phosphorylates myosin and initiates contraction. READ MORE

7. 15. Endothelium-derived Vasoactive Factors and Leukocyte-derived Inflammatory Mediators. Studies in subjects with or at risk for vascular disease

   Author : Anwaar M Ibrahim; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostacyclin.; Postmenopausal hormone replacement therapy; Nitric oxide; Endothelin; Diabetes mellitus; Cytokines; Cholesterol; Atherosclerosis; Cerebral ischemia; Cardiovascular system; Kardiovaskulära systemet;

   Abstract : This study was undertaken to evaluate relationships between endothelial function (assessed as mediators of endothelium-derived vasoactive factors such as nitric oxide [NO], prostacyclin [PGI2] and endothelin [ET-1] ), and risk factors for atherosclerosis, as well as to study possible relationships between endothelial function and leukocyte activation (indicated by measurements of leukocyte-derived inflammatory mediators) in subjects with or at risk for atherosclerosis. In subjects with asymptomatic atherosclerosis we found inverse relationships between cyclic guanosine monophosphate (cGMP) in platelets (mediator of NO activity) and both serum total cholesterol and plasma ET-1 suggesting that NO-mediated vasodilation may be impaired in hypercholesterolemia and that maintenance of vascular tone is achieved by a balance between NO and ET-1. READ MORE