Search for dissertations about: "calpain"

Showing result 1 - 5 of 40 swedish dissertations containing the word calpain.

  2. 1. Calpain-Mediated Apoptosis in Motor Neurons of Adult Mouse Spinal Cord Slices

    Author : HamidReza Momeni; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Calpain; Djurfysiologi; Animal physiology; Spinal cord; Organ culture; Mouse; Motor neurons; Caspase; Calpain inhibitor; Calpain activity; Apoptosis;

    Abstract : Motor neuron degeneration is a critical phenomenon during spinal cord injuries and some neurodegenerative diseases. However, the mechanisms by which cell death is induced in these neurons are poorly understood. READ MORE

  4. 2. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia

    Author : Michel Ferrand-Drake; Lund Wallenberg Neurocentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; neuronal death; calpain; caspase; mitochondrial permeability transition; necrosis; apoptosis; cerebral ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia Following prolonged disruption of blood flow to the central nervous system (CNS), or energy deprivation by other means, such as hypoglycemia, some cells will inevitably degenerate. It has been, and still is, the subject of considerable debate and intense research on brain ischemia, as to the mode of cell death, i. READ MORE

  5. 3. Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia

    Author : Ulrika Hallin; Göteborgs universitet; []
    Keywords : neonatal; rat; brain; hypoxia-ischemia; necrosis; apoptosis; calpain; caspase; Bcl-2; Bax; mitochondria; calcineurin.;

    Abstract : The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to undergo programmed cell death, apoptosis, since this genetic program is normally activated in some cells during development of the nervous system, even in the perinatal period. READ MORE

  6. 4. Ischemic Tolerance and Cell Signaling in the Rat Brain

    Author : Mehrdad Shamloo; Lund Wallenberg Neurocentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; preconditioning; cell death; tyrosine phosphorylation; tolerance; ERK; Calpain; CaMKII; PKC; protection; Brain; ischemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : A brief period of sublethal ischemia in the brain induces resistance to a subsequent, otherwise lethal ischemic insult. This phenomenon is known as ischemic tolerance or preconditioning. A model of ischemic preconditioning in the rat brain using the two-vessel occlusion model of global cerebral ischemia was established. READ MORE

  7. 5. Regulation of apoptosis in the thyroid epithelium

    Author : Abeba Demelash; Göteborgs universitet; []
    Keywords : Thyroid; Apoptosis; Caspase; Calpain; Hydrogen peroxide; TGF-beta; Staurosporine; Selenium; Cytochrome c;

    Abstract : Apoptosis or programmed cell death allows the multicellular organism to remove cells that are in excess or potentially dangerous. Apoptosis has to be strictly controlled, yet inappropriately activated or suppressed apoptototic may contribute to a variety of diseases, including cancer, autoimmune disorders and neurodegenerative conditions. READ MORE