Search for dissertations about: "cancer and osteoporosis"

Showing result 1 - 5 of 19 swedish dissertations containing the words cancer and osteoporosis.

  2. 1. On the Role of Osteoprotegerin/RANK/RANKL System in the Interaction between Prostate Cancer and Bone

    Author : Hendrik Penno; Östen Ljunggren; Olof Nilsson; Andreas Kindmark; Pernilla Lundberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metastases; bone; prostate cancer; osteoprotegerin; RANKL; osteoporosis; genetics; polymorphisms; Orthopaedics; Ortopedi;

    Abstract : Metastases to bone are observed in around 80% of prostate cancer patients and represent the most critical complication of advanced prostate cancer. Unlike other solid tumors that are associated with osteolytic bone metastases, prostate cancer bone metastases stimulate osteoblastic activity with sclerosis in the bone lesions as a consequence. READ MORE

  4. 2. Immune regulation by selective estrogen receptor modulators

    Author : Angelina I Bernardi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Endocrinology; Mice; Lasofoxifene; Bazedoxifene; Raloxifene; Estrogen; Osteoporosis; B cells; T cells; Rheumatoid arthritis;

    Abstract : At menopause, the levels of estrogen decline, leading to loss of estrogen-mediated protective effects on bone and an increased risk of osteoporosis. Hormone replacement therapy, containing estrogen, has been used for many years to prevent and treat osteoporosis in postmenopausal women. READ MORE

  5. 3. Blood and Bone - Epidemiological studies on the association between blood and bone

    Author : Hallgerdur Lind Kristjansdottir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood; Bone; Fractures; Osteoporosis;

    Abstract : Introduction: Preclinical and clinical studies have suggested that blood- and bone cells are interconnected. Aims: To study the association between hematological variables, specifically serotonin, erythropoietin (EPO), hemoglobin (Hb), neutrophil-, lymphocyte-, and platelet count, and bone mineral density (BMD), and/or risk for fractures (paper I-III). READ MORE

  6. 4. New sensitive and specific methods for sex steroid measurements in rodent serum and tissues

    Author : Maria E. Nilsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex steroids; mass spectrometry; rodents;

    Abstract : Accurate measurement of sex steroids (androgens, estrogens, and progesterone) is essential in research and clinical settings for common diseases including osteoporosis, prostate cancer, breast cancer, and cardiovascular diseases. Sex steroids are not only produced in the gonads and adrenals but may also be locally synthesized in peripheral target tissues. READ MORE

  7. 5. Mortality and morbidity in patients with Addison's disease

    Author : Ragnhildur Bergthorsdottir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addison s disease; mortality; glucocorticoid s ; glucocorticoid replacement therapy; cardiovascular diseases; bone mineral density; osteoporosis; quality of life;

    Abstract : Addison's disease (AD) or primary adrenal insufficiency is a rare disease with an estimated prevalence of 100-140 per million inhabitants and deadly unless treated with glucocorticoids (GCs). Very limited information is available on the morbidity and mortality in this patient group. READ MORE