Search for dissertations about: "cancer genomics"

Showing result 1 - 5 of 38 swedish dissertations containing the words cancer genomics.

2. 1. Cancer risk and predisposition in families with childhood cancer

   Author : Karl-Johan Stjernfelt; Lund Pediatrik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Pediatric; Childhood Cancer; Heredity; Genetics; predisposition; Familial cancer;

   Abstract : BACKGROUND: Recent whole genome sequencing studies report that up to 6% of the childhood cancer population harbour a pathogenic variant. Identification of families with hereditary cancer may improve early detection of cancer as well as treatment outcome. READ MORE

4. 2. Pan-cancer study of transcriptional responses to oncogenic somatic mutations

   Author : Arghavan Ashouri; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Driver mutations; Genomics; Transcriptomics; lncRNAs; NRF2; ALK;

   Abstract : Cancer cells typically carry acquired somatic mutations in key cancer driver genes, which can be identified on the basis of recurrence in cancer cohorts. Such mutations may cause aberrant protein activity and altered gene expression in the nucleus, driving the cell toward a cancerous phenotype. READ MORE

5. 3. Genomic mutational heterogeneity in cancer. lmproved models and tools for driver gene detection

   Author : Martin Boström; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; genomics; ultraviolet light; mutational heterogeneity;

   Abstract : Cancer is a disease that is strongly related to evolution, as mutations that confer a benefit to individual cells face positive selection and eventually lead to tumorigenesis. As such, the search for genes that drive cancer development entails distinguishing positive selection from other sources of increased mutation rates, which requires detailed knowledge of how normal mutation rates vary across the genome. READ MORE

6. 4. Computational exploration of cancer genomes

   Author : Joakim Karlsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

   Abstract : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. READ MORE

7. 5. Multi-level characterization of host and pathogen in Helicobacter pylori-associated gastric carcinogenesis

   Author : Kaisa Thorell; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastroenterology; cancer; infection; Helicobacter pylori; sequencing; genomics; transcriptomics; genomics;

   Abstract : Today, more than half of the world’s population is infected with Helicobacter pylori, and two to three per cent of these will develop gastric cancer associated with this infection. Gastric cancer is today the third largest cause of cancer mortality worldwide, with more than 700 000 deaths annually, a number that is expected to increase. H. READ MORE