Search for dissertations about: "cancer mitochondria"

Showing result 1 - 5 of 76 swedish dissertations containing the words cancer mitochondria.

  2. 1. Quiescent cancer cells : Three-dimensional cell models for evaluation of new therapeutics

    Author : Frida Ek; Mårten Fryknäs; Malin Jarvius; Rolf Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cancer cell quiescence; dormancy; three-dimensional; multicellular tumor spheroids; model development; cancer pharmacology; mitochondria; OXPHOS; colorectal carcinoma; hepatocellular carcinoma; Medicinsk vetenskap; Medical Science;

    Abstract : Inadequate metabolic conditions in solid tumors lead to the formation of quiescent cancer cells that are suspended in a transient cell cycle arrest. When conditions change, quiescent cancer cells can re-enter the cell cycle and cause recurrence. READ MORE

  4. 2. Role of mitochondria in early molecular diagnosis and prognosis of cancer

    Author : Yanni Li; Allmänmedicin och klinisk epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; mtDNA copy number; mitochondrial-related nuclear genes; mtDNA mutations; diagnosis; prognosis; biomarker;

    Abstract : Background:Earlier clinical detection of cancer may improve survival as well as offer opportunities for less invasive treatment options. This thesis explores whether the mitochondria and its related genes in the nuclear genome can be used as novel methods for the diagnosis and prognosis of cancers. READ MORE

  5. 3. Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer

    Author : Johannes Gubat; Padraig D´arcy; Stig Linder; Maria Turkina; Per Lindahl; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Deubiquitinase; b-AP15; Ubiquitin-proteasome system;

    Abstract : Cancer is the second leading cause of death globally and is one of the most pressing health issues today. While significant advances have been made in cancer treatment, drug resistance and toxicity remain formidable obstacles to successful therapy. Thus, there is a need to find novel targets that pave the way for new cancer therapeutics. READ MORE

  6. 4. LTD4 signalling via beta-catenin: a possible link between inflammation and cancer

    Author : Maryna Mezhybovska; Malmö Cellpatologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTD4; beta-catenin; colorectal cancer; CysLT1R; proliferation; inflammation;

    Abstract : The pro-inflammatory mediator LTD4 is an important component in the pathogenesis of inflammatory conditions as inflammatory bowel diseases. Patients suffering from inflammatory bowel diseases face an increased risk of intestinal cancer development. READ MORE

  7. 5. Regulation of Polyamine Analogue-Induced Apoptosis in Human Breast Cancer Cells

    Author : Martina Holst; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cancer; Animal physiology; Djurfysiologi; Pharmacological sciences; pharmacognosy; pharmacy; onkologi; Cytologi; cancerology; oncology; Cytochrome c; Cytology; Bcl-2; Mitochondrial respiration; Apoptosis; Human breast cancer cells; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Social medicine; Socialmedicin; samhällsmedicin; Mitochondria; Polyamine analogues;

    Abstract : Apoptosis is a defined process for cells to commit suicide through a set of biochemical and morphological cell changes. Activated apoptotic signals converge on the mitochondria, leading to permeabilization of mitochondrial membranes and release of different apoptosis regulatory proteins into the cytosol. READ MORE