Search for dissertations about: "candidate gene"

Showing result 1 - 5 of 503 swedish dissertations containing the words candidate gene.

  1. 1. Prognostic markers in acute myeloid leukemia A candidate gene approach

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Ingrid Jakobsen; Linköpings universitet.; Linköpings universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. READ MORE

  2. 2. Genetic Analysis of Quantitative Traits Using Domestic Animals A Candidate Gene and Genome Scanning Approach

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hee-Bok Park; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Domestication; horse; pig; chicken; quantitative traits; candidate gene; genome scan; PRKAG3; MC4R; selection experiment; growth; correlated response; metabolic disorders; Quantitative Trait Loci; linkage; single nucleotide polymorphisms; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Abstract : Domestication has led to genetic changes that affect quantitative traits in farm animals. Both candidate gene analysis using association tests and genome scans based on linkage analysis have been performed to understand the molecular basis underlying quantitative genetic variation in horses, pigs and chickens. READ MORE

  3. 3. Genetic studies on Systemic Lupus Erythematosus A fine mapping and candidate gene approach

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Veronica Magnusson; Uppsala universitet.; [2002]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). READ MORE

  4. 4. Hypospadias : Gene mapping and candidate gene studied

    University dissertation from Stockholm : Karolinska Institutet, Department of Women's and Children's Health

    Author : Thi Thai Hanh Trinh; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of hypospadias is 1.14 per 300 male live-births according to the annual Swedish Malformation Registry. READ MORE

  5. 5. Adipose tissue gene expression & candidate genes for obesity

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Lovisa Johansson; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

    Abstract : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. READ MORE