Search for dissertations about: "candidate gene"

Showing result 11 - 15 of 577 swedish dissertations containing the words candidate gene.

  2. 11. Gene therapy by enzyme replacement for Parkinson’s disease Optimization of continuous DOPA delivery and development of a candidate vector for clinical application

    Author : Tomas Björklund; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serotonin; Parkinson’s disease; L-DOPA; dyskinesia; GTP cyclohydrolase 1; tyrosine hydroxylase; dopamine; gene therapy; enzyme replacement; gene regulation; aromatic L-amino acid decarboxylase;

    Abstract : The introduction of L-DOPA pharmacotherapy revolutionized the treatment of Parkinson’s disease close to fifty years ago. Before the discovery of dopamine as a neurotransmitter and its involvement in the disease, these patients had very little aid from medication and were bound to a life without movement. READ MORE

  4. 12. Gene Expression Patterns in a Rat Model of Human Endometrial Adenocarcinoma

    Author : Sandra Karlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rat; complex disease; Endometrial adenocarcinoma; gene expression profiling; cDNA microarrays; candidate genes; Molecular biology; Medical sciences;

    Abstract : Endometrial cancer develops from the endometrium of the uterus and is the most common pelvic malignancy diagnosed in women in the western society. Similar to all cancer diseases, endometrial cancer is a disorder that results from complex patterns of genetic and epigenetic alterations involved in the malignant transformation. READ MORE

  5. 13. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

    Author : Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

    Abstract : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. READ MORE

  6. 14. Graph theory based approaches for gene prioritization in biological networks : Application to cancer gene detection in medulloblastoma

    Author : Hrafn Holger Weishaupt; Sergei Silvestrov; Erik Bongcam-Rudloff; Mälardalens högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mathematics Applied Mathematics; matematik tillämpad matematik;

    Abstract : Networks provide an intuitive and highly adaptable means to model relationships between objects. When translated to mathematical graphs, they become further amenable to a plethora of mathematical operations that allow a detailed study of the underlying relational data. READ MORE

  7. 15. Single-cell RNA sequencing provides novel insights into spider development and represents an innovative alternative to study the evolution and development of panarthropods

    Author : Brenda Irene Medina-Jiménez; Ralf Janssen; Graham Budd; Angelika Stollewerk; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; panarthropod; spider embryo; single-cell RNA sequencing; EvoDevo; candidate gene approach; gene expression; cluster marker; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Earth Science with specialization in Historical Geology and Palaeontology; Geovetenskap med inriktning mot historisk geologi och paleontologi;

    Abstract : Panarthropoda is a monophyletic group of invertebrate animals with a segmented body, paired appendages, dorsal brain, and ventral nerve cords. In order to study the mechanisms underpining their evolution, I study the genetic factors that drive their development. READ MORE