Search for dissertations about: "candidate genes"

Showing result 16 - 20 of 556 swedish dissertations containing the words candidate genes.

  2. 16. Prognostic markers in acute myeloid leukemia : A candidate gene approach

    Author : Ingrid Jakobsen; Kourosh Lotfi; Henrik Gréen; Anna Fyrberg; Christian Thiede; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. READ MORE

  4. 17. Genetic studies on Systemic Lupus Erythematosus : A fine mapping and candidate gene approach

    Author : Veronica Magnusson; Jerry Lanchbury; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Systemic Lupus Erythematosus; complex disease; linkage analysis; candidate gene; association studies; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Abstract : Linkage in the 2q37 region was evaluated using microsatellite markers in multi-case families from Sweden, Iceland and Norway. Both the two-point and the multipoint linkage analysis show highly significant LOD scores (Z=4.51 and 6.03, respectively). READ MORE

  5. 18. Identification and Characterization of Novel Candidate Oncogenes

    Author : Marina Mencinger; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk genetik; Clinical genetics; RBP56; APRIL; TFG; FUS; EWS; EST database; fusion genes; chromosome; molecular genetics; cancer; Cytology; oncology; cancerology; Cytologi; onkologi;

    Abstract : Using computer-assisted sequence homology searches we identified three genes encoding proteins similar to certain fusion partner proteins in cancer. The novel APRIL gene was localized to 15q25 and encodes a protein, containing an acidic amino-acid region similar to that/those of leukemia-associated fusion partner proteins DEK and SET. READ MORE

  6. 19. Welander distal myopathy : gene mapping and analysis of candidate genes

    Author : Désirée von Tell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Welander Distal Myopathy; 2p13; linkage; candidate genes; founder mutation; mutation screening.;

    Abstract : Distal myopathies constitute of a very heterogeneous group of muscular disorders. Distal myopathies have previously been classified according to features such as; clinical symptoms, age of onset and histopathological changes. READ MORE

  7. 20. Functional Genomics of Bone Metabolism : Novel Candidate Genes Identified by Studies in Chicken Models

    Author : Carl-Johan Rubin; Andreas Kindmark; Östen Ljunggren; Leif Andersson; David Burt; Uppsala universitet; []
    Keywords : Molecular medicine; QTL; Bone; Osteoporosis; Gene expression; Microarray; Domestication; Molekylärmedicin;

    Abstract : Osteoporosis is a disease that leads to decreased bone mineral density (BMD), an altered bone micro-architecture and fragile bones. The disease is highly heritable and numerous genes are thought to be involved, making it difficult to identify the causative genetic elements. READ MORE