Search for dissertations about: "capacitance islet"

Found 5 swedish dissertations containing the words capacitance islet.

  2. 1. Electrophysiology of pancreatic A-, B- and D-cells studied in intact mouse islets of Langerhans

    Author : Sven Göpel; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; somatostatin; glucagon; insulin; patch-clamp; membrane potential; Pancreatic islet; ion channel; diabetes; Physiology; Fysiologi;

    Abstract : Abstract The electrophysiological properties of insulin-secreting b-cells, glucagon-releasing a-cells and somatostation-producing d-cells in intact mouse pancreatic islets were investigated using the perforated patch whole-cell technique. It is demonstrated that it is possible to functionally identify the different cell types in situ. READ MORE

  4. 2. Cell coupling and exocytosis measured in intact mouse pancreatic islets Control of {delta}-cell secretion

    Author : Quan Zhang; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Patch-clamp and capacitance measurements were applied to α-, β- and δ-cells in intact mouse pancreatic islets. The maximum rate of β-cell exocytosis during a depolarization to 0 mV was 14 granules/s, ... READ MORE

  5. 3. Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA

    Author : Jovita Karanauskaite; Islet cell physiology; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; LDCV; Insulin; exocytosis; Compound Exocytosis; Calcium;

    Abstract : Several high resolution electrophysiological techniques such as measurements of cell membrane capacitance and amperometry are used to detect exocytotic events. A novel method was developed in this study based on the expression of P2X2 receptor channel in secreting cells. READ MORE

  6. 4. Studies on proteins involved in the molecular regulation of insulin exocytosis

    Author : Wei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Actin; ADP; ATP; Ca2 channel; CAPS; beta-cells; CSP; exocytosis; GK rat; insulin; islet; Mint; Munc-18; NSF; PI 4-kinase; PI 4 P; PI 4; 5 P2; alpha-SNAP; SNAP-25; synaptotagmin III; syntaxin; tomosyn; type 2 diabetes mellitus; VAMP-2.;

    Abstract : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. READ MORE

  7. 5. Mechanisms of type 1 diabetic serum-induced hyperactivation of CaV1 channels in the pancreatic β cell

    Author : Yue Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The pancreatic β cell relies on appropriate Ca2+ entry through voltage-gated calcium (CaV) channels to accomplish its unique function insulin secretion and to guarantee its viability. Well-regulated β cell CaV channels are critical to ensure adequate functional β cell mass, thereby maintaining adequate insulin release and glucose homeostasis in the body. READ MORE