Search for dissertations about: "carbapenemases"
Showing result 6 - 10 of 15 swedish dissertations containing the word carbapenemases.
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6. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli
Abstract : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. READ MORE
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7. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development
Abstract : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. READ MORE
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8. Extremely drug resistant E. coli and K. pneumoniae : novel approaches against their spread and related infections
Abstract : Antibiotic resistance in Enterobacteriaceae is a well-established hindrance and the spread of pathogenic high-risk clones harboring extended-spectrum -lactamases (ESBLs) and carbapenemases is posing a global health challenge, due to very less treatment alternatives. Particular lineages from the major representative species E. coli and K. READ MORE
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9. On the Origins of mobile Antibiotic Resistance Genes : A comparative genomics approach
Abstract : Mobile antibiotic resistance genes (ARGs), transferable between bacterial cells, are major contributors to the antibiotic resistance crisis we are facing today. From which organisms pathogens acquired these genes is mostly unknown, yet knowledge about their origin is needed in order to limit the emergence and spread of novel ARGs in the future. READ MORE
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10. Multidrug-resistant Enterobacterales in Oman : molecular epidemiology and therapeutic insights
Abstract : The spread of antibiotic resistance is a concerning issue causing limited treatment options for bacterial infections, particularly with Gram-negative bacteria. Surveillance and epidemiological studies help to determine the magnitude of the problem as well as to establish early measures to slow down the spread of resistance and consequently increase antibiotic lifespan. READ MORE